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Pathophysiologic mechanisms underlying emphysema and osteoporosis

Research Project

Project/Area Number 26860617
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Respiratory organ internal medicine
Research InstitutionKeio University

Principal Investigator

Sasaki Mamoru  慶應義塾大学, 医学部, 助教 (90573311)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords慢性閉塞性肺疾患 / 骨粗鬆症 / 喫煙曝露 / マウス / 骨代謝 / 骨強度 / 骨質 / 肺気腫 / 骨密度
Outline of Final Research Achievements

The pathophysiologic mechanisms underlying emphysema and osteoporosis have not been fully elucidated. The aim of this study is to determine the effects of short- and long-term cigarette smoke (CS) exposure on bone metabolism, structure and histological changes in a mouse model of CS-induced emphysema. And we examined the effects of cigarette smoke extract (CSE) on the osteoclast-like cell in vitro.
In vivo, both bone resorption and formation markers were significantly decreased in short-term CS-exposed mice. However, those are inversely increased in long-term CS-exposed mice compared to air controls, implying a dynamic shift of bone metabolism from low- toward high-turnover. Bone volume of CS-exposed mice was increased, but bone histomorphometric analysis revealed the increase of osteoclasts. In vitro, CSE directly impaired the differentiation of osteoclast-like cells, this findings partly explain a phenomenon observed in vivo short-term CS exposed mice.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Invited: 1 results)

  • [Journal Article] Evaluation of cigarette smoke-induced emphysema in mice using quantitative micro computed tomography.2015

    • Author(s)
      Mamoru Sasaki
    • Journal Title

      American Journal of Physiology Lung Cellular and Molecular Physiology

      Volume: 印刷中 Issue: 10 Pages: L1039-L1045

    • DOI

      10.1152/ajplung.00366.2014

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Cigarette smoke-induced dynamic changes in bone metabolism and structure along with development of pulmonary emphysema in mice2015

    • Author(s)
      Mamoru Sasaki
    • Organizer
      America Thoracic Society International Conference
    • Place of Presentation
      デンバー コロラド アメリカ
    • Year and Date
      2015-05-15 – 2015-05-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 喫煙はマウスの骨吸収を抑制し骨密度増加を促す2014

    • Author(s)
      佐々木 衛
    • Organizer
      第32回 日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-07-24 – 2014-07-25
    • Related Report
      2014 Research-status Report
  • [Presentation] COPDにおける肺気腫病変と骨粗鬆症の関連2014

    • Author(s)
      佐々木 衛
    • Organizer
      第88回 閉塞性肺疾患研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-19
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 喫煙誘導性肺気腫マウスにおける骨代謝2014

    • Author(s)
      佐々木 衛
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2014-04-25 – 2014-04-27
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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