| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Comparison of survival rates in Legionella infection in wild type mouse, IL-17A deficient mice, IL-17F deficient mice, IL-17AF deficient mice showed a significant survival rate in IL-17AF deficient mice group compared with wild type mouse group Decreased.
At this time, it was suggested that IL-17F plays an important role in defense against Legionella infection as IL-17A, because IL-17F is overproduced after infection in IL-17A deficient mice. In addition, IL-17F was found to be mainly produced from gamma delta (γδ) T cells which are natural lymphocytes in the acute stage of infection.
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