Activating hypoxia response for improving functions of renal EPO producing cells.
| Project/Area Number |
26860623
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
Souma Tomokazu 東北大学, 医学系研究科, 非常勤講師 (20722531)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 腎性貧血 / 低酸素応答 / 腎エリスロポエチン産生細胞 / 貧血 / 線維化 / 低酸素 |
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| Outline of Final Research Achievements |
This research project aimed to understand how renal erythropoietin-producing cells (REPCs) lose their physiological function and gain pathological characteristics under kidney injury. We used multiple mouse models and elucidated that the hypoxia signaling cascade is attenuated in inflammatory milieu in injured kidneys. We further found that activating hypoxia signaling by means of inhibiting HIF proryl hydroxylase, a master negative regulatory system of hypoxia responses, restored REPCs physiological function in hypoxic injured kidneys. Our research provides an explanation how PHD inhibitors, which are clinical trial for renal anemia, might work in injured kidneys in CKD patients.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling2016
Author(s)
Tomokazu Souma, Masahiro Nezu, Daisuke Nakano, Shun Yamazaki, Ikuo Hirano, Hiroki Sekine, Takashi Dan, Kotaro Takeda, Guo-Hua Fong, Akira Nishiyama, Sadayoshi Ito, Toshio Miyata, Masayuki Yamamoto, Norio Suzuki
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Journal Title
Journal of the american society of nephlorogy
Volume: 27
Issue: 2
Pages: 428-438
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity.2016
Author(s)
Souma T, Tompson SW, Thomson BR, Siggs OM, Kizhatil K, John S, Wiggs JL, Pasutto F, Craig JE, Jin J, Quaggin SE, Young TL.
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Journal Title
J Clin Invest.
Volume: 126
Issue: 7
Pages: 2575-2575
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes.2015
Author(s)
Tojo Y, Sekine H, Hirano I, Pan X, Souma T, Tsujita T, Kawaguchi S, Takeda N, Takeda K, Fong GH, Dan T, Ichinose M, Miyata T, Yamamoto M, Suzuki N.
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Journal Title
Mol Cell Biol.
Volume: 35
Issue: 15
Pages: 2658-2672
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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