| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We performed transgenic reporter mouse analyses to analyze a mechanism of renal Epo gene regulation. We have found that a 13.8-kbp region (CURE region), spanning the region from 17.4 kb to 3.6 kb upstream of the Epo gene, is necessary for renal Epo gene regulation. we have also found that mice lacking the CURE region suffer from severe anemia caused by the EPO-deficiency. We named the anemic mice “AnRED (anemic model with renal EPO deficiency) mice”.
CURE region harbors several phylogenetically conserved elements between humans and mice (among mammals). Our results obtained by transgenic reporter mouse analyses show that these elements redundantly and cooperatively work for the regulation of Epo gene in renal EPO-producing cells.
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