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Establishment of novel diagnostic modality of IgG4-related disease and study of its pathophysiology and tumoriogenesis

Research Project

Project/Area Number 26860637
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Kidney internal medicine
Research InstitutionKochi University

Principal Investigator

Taniguchi Yoshinori  高知大学, 教育研究部医療学系臨床医学部門, 助教 (70584431)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
KeywordsIgG4関連疾患 / 線維化 / 臓器機能不全 / 肉芽腫 / サイトカイン / コリンエステラーゼ(ChE) / DKK-1 / IL-4 / インターフェロンγ(IFNγ) / IFNγ / Wntシグナル / Dkk-1 / コリンエステラーゼ / FDG-PET/CT
Outline of Final Research Achievements

Serum ChE levels were significantly lower in IgG4RD with multiple lesions group than with limited lesions, ANCA-associated vasculitis and Sjogren syndrome groups. In total IgG4-RD cases, ChE levels inversely correlated with number of organ involvement (NOI) and fibrotic score, and fibrotic score positively correlated with NOI. Finally, Dkk-1, one of Wnt inhibitors, levels in IgG4RD with multiple lesions were significantly lower than with limited lesions and healthy subjects (p<0.05). Moreover, low level of Dkk-1 before and after treatment possibly predicted the progression of organ atrophy.
Furthermore, frequency of history or onset of malignancy were significantly higher in IgG4RD group than non-IgG4RD group. This result suggested possible relationship between local chronic inflammation and tumorigenesis.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (26 results)

All 2017 2016 2015 2014

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 4 results) Presentation (13 results) (of which Int'l Joint Research: 7 results,  Invited: 1 results)

  • [Journal Article] IgG4-related disease with extensive granulomatous changes2017

    • Author(s)
      Taniguchi Y, Kawano M, Zen Y, Aoyama N, Terada Y
    • Journal Title

      Rheumatology (Oxford)

      Volume: 印刷中 Issue: 8 Pages: 1430-1433

    • DOI

      10.1093/rheumatology/kex154

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Frequency of reactive arthritis, uveitis, and conjunctivitis in Japanese patients with bladder cancer following intravesical BCG therapy: A 20-year, two-centre retrospective study2017

    • Author(s)
      Taniguchi Y, Nishikawa H, Karashima T, Yoshinaga Y, Fujimoto S, Terada Y
    • Journal Title

      Joint Bone Spine

      Volume: 印刷中 Issue: 5 Pages: 637-638

    • DOI

      10.1016/j.jbspin.2016.09.014

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Retinal and Choroidal Detachment in Antineutrophil Cytoplasmic Antibody-Associated Scleritis and Retinal Vasculitis Mimicking Choroidal Tumor2017

    • Author(s)
      Matsuura M, Taniguchi Y, Terada Y
    • Journal Title

      JCR: Journal of Clinical Rheumatology

      Volume: 23 Issue: 4 Pages: 236-237

    • DOI

      10.1097/rhu.0000000000000539

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ultrasonographic findings as diagnostic and follow-up tool in cranial giant cell arteritis2017

    • Author(s)
      Taniguchi Y, Nishikawa H, Amano E, Fujimoto S, Terada Y
    • Journal Title

      QJM: An International Journal of Medicine

      Volume: 110 Issue: 12 Pages: 851-852

    • DOI

      10.1093/qjmed/hcx174

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Factors related to renal cortical atrophy development after glucocorticoid therapy in IgG4-related kidney disease: a retrospective multicenter study.2016

    • Author(s)
      Mizushima I, Yamamoto M, Inoue D, Nishi S, Taniguchi Y, Ubara Y, Matsui S, Yasuno T, Nakashima H, Takahashi H, Yamada K, Nomura H, Yamagishi M, Saito T, Kawano M.
    • Journal Title

      Arthritis Res Ther.

      Volume: 25 Issue: 1 Pages: 273-273

    • DOI

      10.1186/s13075-016-1175-y

    • NAID

      120006325353

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical implications of ultrasonography in monitoring disease activity of relapsing polychondritis2016

    • Author(s)
      Taniguchi Y, Nishikawa H, Nakayama S, Amano E, Terada Y
    • Journal Title

      Rheumatology (Oxford)

      Volume: 55 Issue: 7 Pages: 1250-1250

    • DOI

      10.1093/rheumatology/kew219

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Granulomatous periostitis and tracheal involvement in sarcoidosis2016

    • Author(s)
      Shimamura Y,Taniguchi Y,Yoshimatsu R,Kawase S,Yamagami T,Terada Y
    • Journal Title

      Rheumatology (Oxford)

      Volume: 55 Issue: 1 Pages: 102-102

    • DOI

      10.1093/rheumatology/kev319

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] IgG4-related kidney disease. Diagnosis and treatment2015

    • Author(s)
      Kawano M, Mizushima I, Yamada K, Taniguchi Y, Saeki T
    • Journal Title

      Japanese Journal of Clinical Immunology

      Volume: 38 Issue: 1 Pages: 8-16

    • DOI

      10.2177/jsci.38.8

    • NAID

      130004875955

    • ISSN
      0911-4300, 1349-7413
    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Small Heat Shock Protein Beta-1 (HSP1)Is Upregulated and Autophagy and Apoptosis of Renal Tubular Cells in Acute Kidney Injury2015

    • Author(s)
      Matsumoto T,Urushido M,Ide H,Ishihara M,Hamada-ode K,Shimamura Y,Ogata K,Inoue K,Taniguchi Y,Taguchi T,Horino T,Fujimoto S,Terada Y
    • Journal Title

      PLOS one

      Volume: 10 Issue: 5 Pages: e0126229-e0126229

    • DOI

      10.1371/journal.pone.0126229

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cyclin I and p35 determine the subcellular distribution of Cdk52015

    • Author(s)
      Hagmann H, Taniguchi Y, Pippin JW, Kauerz HM, Benzing T, Shankland SJ, Brinkkoetter PT
    • Journal Title

      American Journal of Physiology Cellular Physiology

      Volume: 308 Issue: 4 Pages: C339-C347

    • DOI

      10.1152/ajpcell.00168.2014

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristics of Japanese patients with reactive arthritis following intravesical BCG therapy for bladder cancer.2014

    • Author(s)
      Taniguchi Y, Terada Y et al.
    • Journal Title

      Mod Rheumatol

      Volume: 25 Issue: 1 Pages: 161-163

    • DOI

      10.3109/14397595.2014.926853

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Serum levels of soluble urokinase plasminogen activator receptor in Japanese patients with chronic kidney disease2014

    • Author(s)
      Taniguchi Y, Terada Y et al.
    • Journal Title

      Kidney International

      Volume: 86 Issue: 1 Pages: 209-210

    • DOI

      10.1038/ki.2014.136

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] IgG4-related tubulointerstitial nephritis accompanied with cystic formation.2014

    • Author(s)
      Fukuhara H, Taniguchi Y, Matsumoto M, Kuroda N, Fukata S, Inoue K, Fujimoto S, Terada Y, Shuin T
    • Journal Title

      BMC Urology

      Volume: 14 Issue: 1 Pages: 1-5

    • DOI

      10.1186/1471-2490-14-54

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] The trend of incidence rate, frequency and HLA phenotype of reactive arthritis and uveitis in Japanese patients with bladder cancer following intravesical BCG therapy: a 20-year, two-center retrospective study2017

    • Author(s)
      Taniguchi Y, Inotani S, Nishikawa H, Inoue K, Horino T, Karashima T, Yoshinaga Y, Terada Y
    • Organizer
      American College of Rheumatology Anuual Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical implication of ultrasonography (US) in monitoring disease activity of relapsing polychondritis (RP) and comparative investigation by US between auricle of RP, repeated trauma and healthy subjects2017

    • Author(s)
      Amano E, Taniguchi Y, Inotani S, Nishikawa H, Matsumoto T, Nakayama S, Terada Y
    • Organizer
      American College of Rheumatology Anuual Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multicenter study on the rate of renal function deterioration in IgG4-related tubulointerstitial nephritis2017

    • Author(s)
      Kawano M, Mizushima I, Taniguchi Y, Saeki T, Nakashima H, Hara S, Fujii H, Yamada K
    • Organizer
      American College of Rheumatology Anuual Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The relationship between serum cholinesterase, number of organ involvement and fibrotic markers in Japanese patients with IgG4-related disease2016

    • Author(s)
      Inotani S, Taniguchi Y, Kawano M, Maeda N, Nishikawa H, Matsuura M, Inoue K, Horino T, Fujimoto S, Terada Y
    • Organizer
      American College of Rheumatology Annual Meeting 2016
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2016-11-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Persistent pruritic skin lesions with dyskeratotic cells in upper layer of epidermis are specific and associated with high levels of serum IL-18 in sdult-onset Still's disease2016

    • Author(s)
      Maeda-Aoyama N, Taniguchi Y, Nakajima K, Shimamura Y, Nishikawa H, Nakayama S, Sano S, Fujimoto S, Terada Y
    • Organizer
      American College of Rheumatology Annual Meeting 2016
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2016-11-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 気管支喘息で通院中に下肢・顔面の神経障害、皮疹、腎機能障害が出現・進行した70歳男性の一例(学生・研修医のための教育セミナー)2016

    • Author(s)
      谷口義典、松本竜季、寺田典生
    • Organizer
      第46回日本腎臓学会西部学術集会
    • Place of Presentation
      シーガイアコンベンションセンター(宮崎県宮崎市)
    • Year and Date
      2016-10-14
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] ミクリッツ病に併発したIgG4関連皮膚病変の一例2016

    • Author(s)
      谷口義典、西川浩文、天野絵梨、松本竜季、大出佳寿、島村芳子、緒方巧二、井上紘輔、堀野太郎、中山修一、寺田典生
    • Organizer
      第60回日本リウマチ学会総会・学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-04-21
    • Related Report
      2016 Research-status Report
  • [Presentation] The relationship between serum cholinesterase, number of organ involvement and fibrotic markers in Japanese patients with IgG4-related disease2015

    • Author(s)
      Nishikawa H, Taniguchi Y, Shimamura Y, Inoue K, Horino T, Nishiyama S, Yoshinaga Y, Terada Y
    • Organizer
      American College of Rheumatology Annual Meeting 2015
    • Place of Presentation
      SanFrancisco, USA
    • Year and Date
      2015-11-08
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The relationship between serum cholinesterase, number of organ involvement and fibrotic markers in Japanese patients with IgG4-related disease2015

    • Author(s)
      Nishikawa H, Taniguchi Y, Shimamura Y, Inoue K, Horino T, Nishiyama S, Yoshinaga Y, Terada Y
    • Organizer
      American Society of Nephrology KIDNEY WEEK 2015
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2015-11-06
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] IgG4関連疾患の臨床的特徴(画像診断および血清学的特徴)2015

    • Author(s)
      谷口義典、刑部有紀、濱田佳寿、松本竜季、島村芳子、緒方巧二、井上紘輔、堀野太郎、寺田典生
    • Organizer
      第58回日本腎臓学会学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2015-06-05
    • Related Report
      2015 Research-status Report
  • [Presentation] IgG4関連疾患におけるコリンエステラーゼ、病変数と血清線維化マーカーの関連2015

    • Author(s)
      大出佳寿、谷口義典、松本竜季、島村芳子、緒方巧二、中山修一、井上紘輔、次田誠、堀野太郎、西山進、吉永泰彦、川野充弘、寺田典生
    • Organizer
      第59回日本リウマチ学会総会・学術集会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2015-04-23 – 2015-04-25
    • Related Report
      2014 Research-status Report
  • [Presentation] IgG4関連疾患の臨床的特徴(血清学的/画像所見の関連)2014

    • Author(s)
      谷口義典、大出佳寿、松本竜季、島村芳子、緒方巧二、井上紘輔、堀野太郎、西山進、吉永泰彦、寺田典生
    • Organizer
      第57回日本腎臓学会学術総会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2014-07-04 – 2014-07-06
    • Related Report
      2014 Research-status Report
  • [Presentation] IgG4関連疾患の臨床的特徴(血清学的/画像所見の関連)2014

    • Author(s)
      大出佳寿、谷口義典、松本竜季、島村芳子、緒方巧二、井上紘輔、堀野太郎、西山進、吉永泰彦、寺田典生
    • Organizer
      第58回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京(グランドプリンスホテル新高輪)
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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