Establishment of novel diagnostic modality of IgG4-related disease and study of its pathophysiology and tumoriogenesis
| Project/Area Number |
26860637
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | Kochi University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
|---|
| Keywords | IgG4関連疾患 / 線維化 / 臓器機能不全 / 肉芽腫 / サイトカイン / コリンエステラーゼ（ChE） / DKK-1 / IL-4 / インターフェロンγ（IFNγ） / IFNγ / Wntシグナル / Dkk-1 / コリンエステラーゼ / FDG-PET/CT |
|---|
| Outline of Final Research Achievements |
Serum ChE levels were significantly lower in IgG4RD with multiple lesions group than with limited lesions, ANCA-associated vasculitis and Sjogren syndrome groups. In total IgG4-RD cases, ChE levels inversely correlated with number of organ involvement (NOI) and fibrotic score, and fibrotic score positively correlated with NOI. Finally, Dkk-1, one of Wnt inhibitors, levels in IgG4RD with multiple lesions were significantly lower than with limited lesions and healthy subjects (p<0.05). Moreover, low level of Dkk-1 before and after treatment possibly predicted the progression of organ atrophy.
Furthermore, frequency of history or onset of malignancy were significantly higher in IgG4RD group than non-IgG4RD group. This result suggested possible relationship between local chronic inflammation and tumorigenesis.
|
Report
(5 results)
Research Products
(26 results)
-
-
-
-
-
[Journal Article] Factors related to renal cortical atrophy development after glucocorticoid therapy in IgG4-related kidney disease: a retrospective multicenter study.2016
Author(s)
Mizushima I, Yamamoto M, Inoue D, Nishi S, Taniguchi Y, Ubara Y, Matsui S, Yasuno T, Nakashima H, Takahashi H, Yamada K, Nomura H, Yamagishi M, Saito T, Kawano M.
-
Journal Title
Arthritis Res Ther.
Volume: 25
Issue: 1
Pages: 273-273
DOI
NAID
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] The relationship between serum cholinesterase, number of organ involvement and fibrotic markers in Japanese patients with IgG4-related disease2016
Author(s)
Inotani S, Taniguchi Y, Kawano M, Maeda N, Nishikawa H, Matsuura M, Inoue K, Horino T, Fujimoto S, Terada Y
Organizer
American College of Rheumatology Annual Meeting 2016
Place of Presentation
Washington DC, USA
Year and Date
2016-11-13
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
