Functional Analysis of Novel MR Binding Factor Evi1 and Clinical Significance of its SNP in Prediction of Hypertension Onset
Project/Area Number |
26860646
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Kidney internal medicine
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Research Institution | Keio University |
Principal Investigator |
Rie Jo 慶應義塾大学, 医学部(信濃町), 共同研究員 (30464861)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | ミネラルコルチコイド受容体 / 転写共役因子 / GWAS解析 / ヒストンメチル化修飾酵素 / Evi-1 / ミネラルコルチコイド受容体(MR) |
Outline of Final Research Achievements |
Mineralocorticoid receptor (MR) is involved in the development of hypertension and its detailed molecular mechanism has been focused. Evi-1 was identified as a candidate for novel MR-interacting protein through LC-MS/MS screening method. Evi-1 has SET domain, which includes histone methylation activity, in the whole molecule “Evi-1c”, but another isoform “Evi-1a”, which lacks SET domain, is supposed to act as dominant negative for Evi-1c. This study elucidated that Evi-1c functions as corepressor of MR but co-expression of Evi-1a suppresses the activity of Evi-1c. The recent GWAS results revealed that a certain SNP of Evi-1 gene is associated with hypertension or chronic kidney disease. It remains to be investigated whether this SNP might determine the ratio of Evi-1c/Evi-1a, leading to the change of MR sensitivity.
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Report
(4 results)
Research Products
(7 results)
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[Presentation] 複数の腫瘍があるPAにおける超選択的副腎静脈サンプリングの意義2015
Author(s)
大嶋 洋佑, 栗原 勲, 宮下 和季, 小林 佐紀子, 横田 健一, 城 理絵, 門松 賢, 武田 彩乃, 小黒 草太, 宮嶋 哲, 亀山 香織, 伊藤 裕
Organizer
第25回臨床内分泌代謝Update
Place of Presentation
東京国際フォーラム(東京都千代田区)
Year and Date
2015-11-27
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[Presentation] 超選択的副腎静脈サンプリング検査を用いたサブクリニカルクッシング症候群合併原発性アルドステロン症の局在判定とその妥当性評価2015
Author(s)
宇都 飛鳥, 栗原 勲, 宮下 和季, 小林 佐紀子, 横田 健一, 武田 彩乃, 城 理絵, 三石 木綿子, 中村 俊文, 盛崎 瑞葉, 高畑 尚, 小黒 草太, 宮嶋 哲, 亀山 香織, 伊藤 裕
Organizer
第38回日本高血圧学会総会
Place of Presentation
愛媛県県民文化会館(愛媛県松山市)
Year and Date
2015-10-09
Related Report
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