| Project/Area Number |
26860646
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
Rie Jo 慶應義塾大学, 医学部(信濃町), 共同研究員 (30464861)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ミネラルコルチコイド受容体 / 転写共役因子 / GWAS解析 / ヒストンメチル化修飾酵素 / Evi-1 / ミネラルコルチコイド受容体（MR） |
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| Outline of Final Research Achievements |
Mineralocorticoid receptor (MR) is involved in the development of hypertension and its detailed molecular mechanism has been focused. Evi-1 was identified as a candidate for novel MR-interacting protein through LC-MS/MS screening method. Evi-1 has SET domain, which includes histone methylation activity, in the whole molecule “Evi-1c”, but another isoform “Evi-1a”, which lacks SET domain, is supposed to act as dominant negative for Evi-1c. This study elucidated that Evi-1c functions as corepressor of MR but co-expression of Evi-1a suppresses the activity of Evi-1c. The recent GWAS results revealed that a certain SNP of Evi-1 gene is associated with hypertension or chronic kidney disease. It remains to be investigated whether this SNP might determine the ratio of Evi-1c/Evi-1a, leading to the change of MR sensitivity.
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