| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The accumulation of mis-folded and/or abnormally modified proteins is a major characteristic of many neurodegenerative diseases. In Lewy body disease (LBD), insoluble α-synuclein is widely deposited in the presynaptic terminals as well as in the neuronal cytoplasm in distinct brain regions. The autophagy-lysosome system is an efficient degradation pathway for abnormal molecules within cells. We investigated the effect of trehalose on abnormal aggregation of α-synuclein in a model of LBD. Trehalose treatment induced autophagy and reduced level of detergent-insoluble α-synuclein, although an apparent alteration was not observed in abnormal aggregation of α-synuclein. These results indicate that the oral intake of trehalose can be a promissing treatment for prevention of accumulation of abnormal α-synuclein, especially before aggregation formation.
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