The pathophysiology and treatment of proteasome inhibitor induced polyneuropathy

• Project/Area Number: 26860659
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Chiba University
• Principal Investigator: Sekiguchi Yukari 千葉大学, 大学院医学研究院, 助教 (10568653)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 化学療法誘発性末梢神経障害 / プロテアソーム阻害薬 / 下肢感覚神経 / 軸索イオンチャネル機能評価 / 化学療法誘発性ポリニューロパチー / プロテオソーム阻害薬 / 化学療法性末梢神経障害 / プロテアソーム阻害剤 / 神経軸索機能検査 / 薬剤性ニューロパチー

Outline of Final Research Achievements

Chemotherapy induced polyneuropathy (CIPN) is one of thr frequent side effect of proteasome inhibitor and become most popular regulatory factor for decreasing the dose.The pathophysiology of CIPN are still unknown and the evaluation is difficult because main symptom is sensory disturbance at lower extremities.
The present study showed that using a near nerve needle would make easier to evaluate nerve excitability in sensory nerve at lower extermities. This technique would contribute to evaluate CIPN which is mainly impared in sensory nerve in lower extremities.

Research Products

• [Journal Article] Pain-related evoked potentials after intraepidermal electrical (2017)
  • Author(s): Omori S, Isose S, Misawa S, Watanabe K, Sekiguchi Y, Shibuya K, Beppu M, Amino
  • Journal Title: Neuroscience Research Volume: 印刷中 Pages: 43-48
  • DOI: 10.1016/j.neures.2017.03.007
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Electrophysiology in Fisher syndrome. (2017)
  • Author(s): Kuwabara S, Sekiguchi Y, Misawa S
  • Journal Title: . Clin Neurophysiol Volume: 128 Pages: 215-219
  • Int'l Joint Research
• [Journal Article] Safety and efficacy of thalidomide in patients with POEMS syndrome: a multicentre, randomised, double-blind, placebo-controlled trial. (2016)
  • Author(s): Misawa S, Sato Y, Katayama K, Nagashima K, Aoyagi R, Sekiguchi Y, Sobue G, Koike H, Yabe I, Sasaki H, Watanabe O, Takashima H, Nishizawa M, Kawachi I, Kusunoki S, Mitsui Y, Kikuchi S, Nakashima I, et al; Japanese POEMS Syndrome for Thalidomide (J-POST) Trial Study Group.
  • Journal Title: Lancet Neurol Volume: 15 Issue: 11 Pages: 1129-37
  • DOI: 10.1016/s1474-4422(16)30157-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] How often and when Fisher syndrome is overlapped by Guillain-Barré syndrome or Bickerstaff brainstem encephalitis? (2016)
  • Author(s): Sekiguchi Y, Mori M, Misawa S, Sawai S, Yuki N, Beppu M, Kuwabara S.
  • Journal Title: Eur J Neurol Volume: 23 Pages: 1058-63
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A Prospective, Multicenter, Randomized Phase II Study to Evaluate the Efficacy and Safety of Eculizumab in Patients with Guillain-Barré Syndrome (GBS): Protocol of Japanese Eculizumab Trial for GBS (JET-GBS). (2016)
  • Author(s): Yamaguchi N, Misawa S, Sato Y, Nagashima K, Katayama K, Sekiguchi Y, et al.
  • Journal Title: JMIR Res Protoc Volume: 5
  • Int'l Joint Research
• [Presentation] Fisher 症候群の電気生理 (2016)
  • Author(s): 関口 縁
  • Organizer: 第46回臨床神経生理学会学術集会
  • Place of Presentation: ホテルハマツ、福島県郡山市
  • Year and Date: 2016-10-27
• [Presentation] CIDP の軸索特性: 臨床病型に基づく検討 (2016)
  • Author(s): 渡辺 慶介、三澤 園子、渋谷 和幹、関口 縁、別府美奈子、網野 寛、
  • Organizer: 第46回臨床神経生理学会学術集会
  • Place of Presentation: ホテルハマツ、福島県郡山市
  • Year and Date: 2016-10-27
• [Presentation] ギラン・バレー症候群の予後予測における神経伝導検査の有用性 (2016)
  • Author(s): 関口 縁、三澤 園子、別府美奈子、澁谷 和幹、渡辺 慶介、網野 寛、桑原 聡
  • Organizer: 第46回臨床神経生理学会学術集会
  • Place of Presentation: ホテルハマツ、福島県郡山市
  • Year and Date: 2016-10-27
  • Invited
• [Presentation] 本邦のGuillan-Barré症候群における人工呼吸器装着リスク (2016)
  • Author(s): 関口 縁、三澤 園子、澁谷 和幹、渡辺 慶介、網野 寛、水地 智基、桑原 聡
  • Organizer: 第28回日本神経免疫学会学術集会
  • Place of Presentation: 長崎ブリックホール、長崎県長崎市
  • Year and Date: 2016-09-29
• [Presentation] 高齢Guillan-Barré症候群患者の予後 (2016)
  • Author(s): 関口 縁、三澤 園子、渡辺 慶介、網野 寛、磯瀬 沙希里、桑原 聡
  • Organizer: 第27回末梢神経学会学術集会
  • Place of Presentation: 大阪国際会議場、大阪府
  • Year and Date: 2016-08-26
• [Presentation] Typical およびAtypical CIDPにおける呼吸不全例の検討 (2016)
  • Author(s): 織田史子、渡辺慶介、三澤園子、関口縁、桑原聡
  • Organizer: 第27回末梢神経学会学術集会
  • Place of Presentation: 大阪国際会議場、大阪府
  • Year and Date: 2016-08-26
• [Presentation] Difference in small fiber involvement in CIDP and POEMS syndrome. (2016)
  • Author(s): Sagiri Isose, Sonoko Misawa, Shigeki Oomori, Yukari Sekiguchi, Minako Beppu, Keisuke Watanabe, Satoshi Kuwabara
  • Organizer: Inflammatory Neuropathy Consortium of the peripheral nerve society
  • Place of Presentation: Glasgow, UK
  • Year and Date: 2016-06-21
  • Int'l Joint Research
• [Presentation] How often is Fisher syndrome overlapped with Guillan-Barre syndrome or Bickerstuff brainstem encephalitis. (2016)
  • Author(s): Yukari Sekiguchi, Sonoko Misawa, Amino Hiroshi, Yuta Iwai, Minako Beppu,Nobuhiro Yuki, Satoshi Kuwabara
  • Organizer: Inflammatory Neuropathy Consortium of the peripheral nerve society
  • Place of Presentation: Glasgow, UK
  • Year and Date: 2016-06-21
  • Int'l Joint Research