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Biomarkers for cerebral amyloid angiopathy-related inflammation

Research Project

Project/Area Number 26860664
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurology
Research InstitutionGifu University

Principal Investigator

Yoshikura Nobuaki  岐阜大学, 医学部附属病院, 助教 (80585654)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsアミロイドβ / アルツハイマー型認知症 / 脳アミロイドアンギオパチー / 抗Aβ抗体 / CAA-ri
Outline of Final Research Achievements

Brain magnetic resonance imaging (MRI) of patients with Alzheimer's disease (AD) sometimes reveals multiple cerebral microbleeds (CMBs) and confluent white matter hyperintensities (WMHs) similar to those observed in cerebral amyloid angiopathy-related inflammation (CAA-I). We investigated the cerebrospinal fluid (CSF) profiles of 38 AD, five amnestic mild cognitive impairment (MCI), and six CAA-I patients. The AD and MCI patients were divided into groups of patients with (n = 10) or without (n = 33) multiple CMBs (n ≧ 2) on T2*-gradient echo sequences of brain MRI. The levels of CSF anti-amyloid β autoantibody, interleukin 8, CSF/serum albumin ratios and immunoglobulin G indexes, were significantly higher in CAA-I patients than the other groups. However, there were no significant differences in the CSF profiles of patients with or without multiple CMBs. Our study provides evidence for different pathophysiological mechanisms underlying these differential MRI findings in AD and CAA-I.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (11 results)

All 2017 2016 2015 2014

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (5 results)

  • [Journal Article] Increased cerebrospinal fluid progranulin correlates with interleukin-6 in the acute phase of neuromyelitis optica spectrum disorder.2017

    • Author(s)
      Kimura A, Takemura M, Saito K, Serrero G, Yoshikura N, Hayashi Y, Inuzuka T.
    • Journal Title

      JOURNAL OF NEUROIMMUNOLOGY

      Volume: 305 Pages: 175-181

    • DOI

      10.1016/j.jneuroim.2017.01.006

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Association between naturally occurring anti-amyloid β autoantibodies and medial temporal lobe atrophy in Alzheimer's disease2017

    • Author(s)
      .Kimura A, Takemura M, Saito K, Yoshikura N, Hayashi Y, Inuzuka T.
    • Journal Title

      J NEUROL NEUROSUR PSYCHIATRY

      Volume: 88 Issue: 2 Pages: 126-131

    • DOI

      10.1136/jnnp-2016-313476

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of cerebrospinal fluid profiles in Alzheimer’s disease with multiple cerebral microbleeds and cerebral-amyloid angiopathy related inflammation.2017

    • Author(s)
      Kimura A, Takemura M, Kuniaki S, Yoshikura N, Hayashi Y, Harada N, Nishida H, Nakajima H, Inuzuka T.
    • Journal Title

      Journal of Neurology

      Volume: 264 Issue: 2 Pages: 373-381

    • DOI

      10.1007/s00415-016-8362-2

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of target antigens of antiendothlial cell antibodies against human brain microvascular endothelial cells in health subjects.2015

    • Author(s)
      1.Kimura A, Sakurai T, Yoshikura N, Koumura A, Hayashi Y, Ohtaki H, Chousa M, Seishima M, Inuzuka T.
    • Journal Title

      Curr Neurovasc Res

      Volume: 12 Pages: 25-30

    • Related Report
      2015 Research-status Report
  • [Journal Article] B-cell-activating factor belonging to the tumor necrosis factor family (BAFF) and a proliferation-inducing ligand (APRIL) levels in cerebrospinal fluid of patients with meningoencephalitis.2015

    • Author(s)
      2.Kimura A, Yoshikura N, Koumura A, Hayashi Y, Inuzuka T.
    • Journal Title

      J Neurol Sci

      Volume: 352 Pages: 79-83

    • Related Report
      2015 Research-status Report
  • [Journal Article] Identification of target antigens of naturally occurring autoantibodies in cerebrospinal fluid.2015

    • Author(s)
      3.Kimura A, Yoshikura N, Koumura A, Hayashi Y, Kobayashi I, Yano T, Inuzuka T.
    • Journal Title

      J Proteomics

      Volume: 128 Pages: 450-457

    • Related Report
      2015 Research-status Report
  • [Presentation] 抗NMDA受容体抗体陽性脳炎における多彩な自律神経症状の出現時期とその対応2016

    • Author(s)
      吉倉 延亮、木村 暁夫、工藤 琢哉、安西 将大、竹腰 顕、山田 恵、林 祐一、犬塚 貴
    • Organizer
      神経免疫学会
    • Place of Presentation
      長崎ブリックホール
    • Year and Date
      2016-09-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] 自己免疫性神経疾患における新規抗血管内皮抗体の同定2016

    • Author(s)
      吉倉延亮、木村暁夫、安西将大、竹腰 顕、林 祐一、犬塚 貴
    • Organizer
      神経学会
    • Place of Presentation
      神戸国際会議場・神戸国際展示場・神戸ポートピアホテル
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] 自己免疫性神経疾患における新規抗血管内皮抗体の同定2015

    • Author(s)
      吉倉 延亮
    • Organizer
      神経免疫学会
    • Place of Presentation
      長良川国際会議場
    • Year and Date
      2015-09-15
    • Related Report
      2015 Research-status Report
  • [Presentation] 脳アミロイドアンギオパチー関連炎症における臨床および髄液所見の検討2014

    • Author(s)
      吉倉 延亮
    • Organizer
      神経免疫学会
    • Place of Presentation
      金沢歌劇座(金沢市)
    • Year and Date
      2014-09-04 – 2014-09-06
    • Related Report
      2014 Research-status Report
  • [Presentation] アルツハイマー型認知症におけるmicrobleedと臨床所見との関連性の検討2014

    • Author(s)
      吉倉 延亮
    • Organizer
      神経学会総会
    • Place of Presentation
      福岡国際センター
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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