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Difference between the blood-brain barrier and blood-nerve barrier: Analyses using new human in vitro blood-brain barrier and blood-nerve barrier models.

Research Project

Project/Area Number 26860669
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurology
Research InstitutionYamaguchi University

Principal Investigator

ABE Masaaki  山口大学, 医学部, 特別医学研究員 (80598748)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsDesert hedgehog / 血液神経関門 / desert hedgehog / 血液脳関門
Outline of Final Research Achievements

Both the blood-brain barrier (BBB) and the blood-nerve barrier (BNB) maintain their respective internal environments as barriers to the nervous system. BBB failure is thought to cause multiple sclerosis and optic neuromyelitis, and BNB failure to cause Guillain - Barre syndrome and CIDP. Clarifying the difference between BBB and BNB, it is considered to reveal the pathology of the autoimmune diseases of the nervous system.
In this study, genes of the BBB cell line (TY10) and the BNB cell line (FH-BNB) were compared using DNA microarray. As a result, expression of genes related to hedgehog signaling pathway was different between both. Among the Hedgehog family, it became clear that desert hedgehog is involved in the difference in barrier function between BBB and BNB.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (9 results)

All 2016 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (6 results)

  • [Journal Article] Markedly Increased IP-10 Production by Blood-Brain Barrier in Neuromyelitis Optica.2015

    • Author(s)
      Shimizu F, Nishihara H, Sano Y, Takeshita Y, Takahashi S, Maeda T, Takahashi T, Abe M, Koga M, Kanda T.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 3 Pages: e0122000-e0122000

    • DOI

      10.1371/journal.pone.0122000

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Fingolimod prevents blood-brain barrier disruption induced by the sera from patients with multiple sclerosis.2015

    • Author(s)
      Nishihara H, Shimizu F, Sano Y, Takeshita Y, Maeda T, Abe M, Koga M, Kanda T.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 3 Pages: e0121488-e0121488

    • DOI

      10.1371/journal.pone.0121488

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Autocrine MMP-2/9 secretion increases the BBB permeability in neuromyelitis optica.2014

    • Author(s)
      Tasaki A, Shimizu F, Sano Y, Fujisawa M, Takahashi T, Haruki H, Abe M, Koga M, Kanda T.
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 85 Issue: 4 Pages: 419-430

    • DOI

      10.1136/jnnp-2013-305907

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Autocrine MMP-9 secreion disrupt the blood-nerve barrier in CIDP.2016

    • Author(s)
      Maeda T, Sano Y, Abe M, Takeshita Y, Nishihara H, Takahashi S, Kanda T.
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      兵庫県神戸市(神戸国際会議場)
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] Desert hedgehogが血液神経関門の バリア機能を制御する2015

    • Author(s)
      安部真彰
    • Organizer
      第26回日本末梢神経学会学術集会
    • Place of Presentation
      長野県松本市(ホテルブエナビスタ)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Difference between the blood-brain barrier and blood-nerve barrier: Analyses using new human in vitro blood- brain and blood-nerve barrier models.2015

    • Author(s)
      Abe M, Sano Y, Nishihara H, Sano H, Takeshita Y, Maeda T, Kanda T
    • Organizer
      2015 annual meeting, American Academy of Neurology
    • Place of Presentation
      Washington DC (USA)
    • Year and Date
      2015-04-18 – 2015-04-25
    • Related Report
      2014 Research-status Report
  • [Presentation] Comparison of endothelial cells constituting blood-brain barrier and blood-nerve barrier, using a DNA microarray2014

    • Author(s)
      Abe M, Sano Y, Nishihara H, Oishi M, Sano H, Shimizu F, Maeda T, Kanda T
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 血液脳関門,血液神経関門構成内皮細胞の遺伝子発現の比較2014

    • Author(s)
      安部真彰,佐野泰照,西原秀昭,大石真莉子,清水文崇,前田敏彦,神田隆
    • Organizer
      第25回 日本末梢神経学会学術集会
    • Place of Presentation
      ホテルルビノ京都堀川(京都市)
    • Year and Date
      2014-08-29 – 2014-08-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 不死化細胞株を用いた血液脳関門,血液神経関門 in vitroモデルの比較2014

    • Author(s)
      安部真彰,佐野泰照,清水文崇,春木明代,前田敏彦,田崎彩子,斉藤和幸,神田 隆
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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