| Project/Area Number |
26860672
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Kumamoto University |
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Principal Investigator |
Misumi Yohei 熊本大学, 大学院生命科学研究部, 助教 (80625781)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | アミロイド / トランスサイレチン / 線維芽細胞 / 筋線維芽細胞 / 細胞外マトリックス / 家族性アミロイドポリニューロパチー |
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| Outline of Final Research Achievements |
I analyzed the function of fibroblast on the pathogenesis of transthyretin (TTR) amyloid fibrils, since fibroblast is one of the major cells of the extracellular matrix, in which amyloid fibrils are formed and degraded.Fragmented TTR amyloid deposited around and inside the fibroblasts, and the structure of amyloid deposits became large size and complicated shape with time, when fibroblasts were cultured with fragmented TTR in the 3D cell culture system. These results suggest the function of fibroblast to increase a density of amyloid fibrils in the extracellular matrix.
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