Function of fibroblast on the clearance of transthyretin amyloid fibrils
Project/Area Number |
26860672
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurology
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Research Institution | Kumamoto University |
Principal Investigator |
Misumi Yohei 熊本大学, 大学院生命科学研究部, 助教 (80625781)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | アミロイド / トランスサイレチン / 線維芽細胞 / 筋線維芽細胞 / 細胞外マトリックス / 家族性アミロイドポリニューロパチー |
Outline of Final Research Achievements |
I analyzed the function of fibroblast on the pathogenesis of transthyretin (TTR) amyloid fibrils, since fibroblast is one of the major cells of the extracellular matrix, in which amyloid fibrils are formed and degraded.Fragmented TTR amyloid deposited around and inside the fibroblasts, and the structure of amyloid deposits became large size and complicated shape with time, when fibroblasts were cultured with fragmented TTR in the 3D cell culture system. These results suggest the function of fibroblast to increase a density of amyloid fibrils in the extracellular matrix.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Effects of tafamidis treatment on transthyretin (TTR) stabilization, efficacy, and safety in Japanese patients with familial amyloid polyneuropathy (TTR-FAP) with Val30Met and non-Varl30Met: A phase III, open-label study.2016
Author(s)
Ando Y, Sekijima Y, Obayashi K, Yamashita T, Ueda M, Misumi Y, Morita H, Machii K, Ohta M, Takata A, Ikeda S.
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Journal Title
J Neurol Sci
Volume: 362
Pages: 266-271
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Long-term outcome of patients with hereditary transthyretin V30M amyloidosis with polyneuropathy after liver transplantation.2016
Author(s)
Okumura K, Yamashita T, Masuda T, Misumi Y, Ueda A, Ueda M, Obayashi K, Jono H, Yamashita S, Inomata Y, Ando Y.
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Journal Title
Amyloid
Volume: 23
Issue: 1
Pages: 39-45
DOI
Related Report
Peer Reviewed
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[Journal Article] Knee osteoarthritis associated with different kinds of amyloid deposits and the impact of aging on type of amyloid.2016
Author(s)
Yanagisawa A, Ueda M, Sueyoshi T, Nakamura E, Tasaki M, Suenaga G, Motokawa H, Toyoshima R, Kinoshita Y, Misumi Y, Yamashita T, Sakaguchi M, Westermark P, Mizuta H, Ando Y.
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Journal Title
Amyloid
Volume: 23
Issue: 1
Pages: 26-32
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Clinico-histopathological and biochemical analyses of corneal amyloidosis in gelatinous drop-like corneal dystrophy.2015
Author(s)
Tasaki M, Ueda M, Matsumoto K, Kawaji T, Misumi Y, Eiki D, Suenaga G, Obayashi K, Yamashita T, Tanihara H, Ando Y.
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Journal Title
Amyloid
Volume: 22
Issue: 1
Pages: 67-69
DOI
Related Report
Peer Reviewed
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[Journal Article] Amyloid deposits derived from transthyretin in the ligamentum flavum as related to lumbar spinal canal stenosis.2015
Author(s)
Yanagisawa A, Ueda M, Sueyoshi T, Okada T, Fujimoto T, Ogi Y, Kitagawa K, Tasaki M, Misumi Y, Oshima T, Jono H, Obayashi K, Hirakawa K, Uchida H, Westermark P, Ando Y, Mizuta H.
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Journal Title
Mod Pathol.
Volume: 28
Pages: 201-207
Related Report
Peer Reviewed
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[Journal Article] Changes in pathological and biochemical findings of systemic tissue sites in familial amyloid polyneuropathy more than 10 years after liver transplantation2013
Author(s)
Oshima T, Kawahara S, Ueda M, Kawakami Y, Tanaka R, Okazaki T, Misumi Y, Obayashi K, Yamashita T, Ohya Y, Ihse E, Shinriki S, Tasaki M, Jono H, Asonuma K, Inomata Y, Westermark P, Ando Y
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Journal Title
J Neurol Neurosurg Psychiatry
Volume: -
Issue: 7
Pages: 740-746
DOI
Related Report
Peer Reviewed
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