| Project/Area Number |
26860679
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
Uruha Akinori 国立研究開発法人国立精神・神経医療研究センター, トランスレーショナル・メディカルセンターゲノム診療開発部, 研究員 (70635078)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 封入体筋炎 / インフラマソーム / 内科 / 病理学 / 免疫学 |
|---|
| Outline of Final Research Achievements |
This study aimed to elucidate if inflammasomes were specifically involved with the pathogenesis of inclusion body myositis. Inflammasome-associated proteins (ASC and NLRP3) frozen biopsied muscle samples were immunohistochemically analyzed. In inclusion body myositis, overexpression of the proteins were observed. Meanwhile, also in other muscle diseases including dermatomyositis, polymyositis, and muscular dystrophies, similar findings were occasionally seen. These results suggest that inflammasomes might be associated with the pathogenesis of inclusion body myositis but the overexpression would not be specific.
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