| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Considering that one of the main reasons of insulin deficiency is a reduction in pancreatic beta cell mass, expanding beta cell mass could represent attractive therapeutic approaches to the treatment of diabetes. We showed that the pancreatic beta cell replication mechanism induced by short-term HF diet feeding in mice involved a glucokinase- and Irs2-independent pathway. Our results suggest that the beta cell replication pathways involved in short-term HF diet feeding may differ from those involved in chronic HF diet feeding. In addition, we demonstrated that sodium glucose co-transporter 2 inhibitor improved glucose tolerance and maintained beta cell mass in the mouse model of type 2 diabetes.
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