Identification of brown-fat derived adipokine that enhances whole body energy expenditure
| Project/Area Number |
26860684
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Hokkaido University |
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Principal Investigator |
Okamatsu Yuko 北海道大学, 獣医学研究科, 講師 (90527178)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 褐色脂肪 / エネルギー代謝 / 脂肪細胞 / 肥満 / エネルギー消費 / 細胞増殖 / アディポカイン / 褐色脂肪組織 |
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| Outline of Final Research Achievements |
Brown adipose tissue dissipates energy as heat, and is expected as therapeutic target for the treatment of obesity. The aim of this study was to clarify the regulative mechanisms of the number of brown adipocytes. Obtained results indicate that the number of brown adipocytes increases by the proliferation of mature brown adipocytes, in addition to the proliferation and differentiation of progenitors into brown adipocytes, and their proliferation is regulated via different types of adrenergic receptor. As expected, increasing the number of brown adipocytes by the adrenergic stimulation resulted in the enhancement of basic energy expenditure. In addition, it was observed that the number of beige adipocytes, inducible type of brown adipocytes, decreased with aging, possibly due to the age-dependent decline in the number of progenitors. These results suggest the importance of the understanding the regulative mechanism of the number of brown/beige adipocytes and their progenitors.
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Report
(4 results)
Research Products
(21 results)
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[Presentation] 寒冷暴露時の褐色細胞組織増生機構2015
Author(s)
深野圭伍，岡松優子，小林純子，坂上浩，木村和弘
Organizer
第20回アディポサイエンス・シンポジウム
Place of Presentation
千里ライフサイエンスセンター、大阪府豊中市
Year and Date
2015-08-22
Related Report
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