| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Brown adipose tissue dissipates energy as heat, and is expected as therapeutic target for the treatment of obesity. The aim of this study was to clarify the regulative mechanisms of the number of brown adipocytes. Obtained results indicate that the number of brown adipocytes increases by the proliferation of mature brown adipocytes, in addition to the proliferation and differentiation of progenitors into brown adipocytes, and their proliferation is regulated via different types of adrenergic receptor. As expected, increasing the number of brown adipocytes by the adrenergic stimulation resulted in the enhancement of basic energy expenditure. In addition, it was observed that the number of beige adipocytes, inducible type of brown adipocytes, decreased with aging, possibly due to the age-dependent decline in the number of progenitors. These results suggest the importance of the understanding the regulative mechanism of the number of brown/beige adipocytes and their progenitors.
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