The exercise regulated hepatic metabolism and the role of IL-6/STAT3/FGF21

Research Project

Project/Area Number	26860690
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Metabolomics
Research Institution	The University of Tokyo
Principal Investigator	Kobayashi Masatoshi 東京大学, 医学部附属病院, 助教 (30396725)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	運動 / 肝臓 / 骨格筋
Outline of Final Research Achievements	Exercise can improve hepatic metabolism. We investigate its mechanism focusing on IL-6, which is excreted from skeletal muscle by exercise, and on STAT3 and FGF21, which activate hepatic glucose and lipid metabolism, and explore an exercise-mimetic treatment. We found that exercise increase the hepatic IRS-2 and phosphorylation of STAT3 in mice. Exercise also increases hepatic FGF21 expression, which was canceled by neutralization with anti-IL-6 antibody. We are investigating further mechanism by which exercise improve hepatic metabolism through IL-6/STAT3/FGF21 in vitro and in vivo.