| Project/Area Number |
26860692
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Itoh Michiko 東京医科歯科大学, 医歯(薬)学総合研究科, 特別研究員 (00581860)
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 慢性炎症 / マクロファージ / crown-like structure |
|---|
| Outline of Final Research Achievements |
Chronic inflammation is one of the most characteristic features of non-alcoholic steatohepatitis (NASH), and macrophages play pivotal role in the process of inflammation. In this study, we focused on the pathophysiological role of "hepatic crown-like structure (hCLS)", where macrophages surround dead hepatocytes in the novel rodent model of human NASH using melanocortin 4 receptor deficient mice. Our data provide evidence that hCLS-constitiuing macrophages are the source of fibrogenic factors, and promote inflammation and fibrosis in the development of NASH.
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