Pathophysiological role of macrophages and leptin in the development of non-alcoholic steatohepaititis
Project/Area Number |
26860692
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Metabolomics
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
Itoh Michiko 東京医科歯科大学, 医歯(薬)学総合研究科, 特別研究員 (00581860)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 慢性炎症 / マクロファージ / crown-like structure |
Outline of Final Research Achievements |
Chronic inflammation is one of the most characteristic features of non-alcoholic steatohepatitis (NASH), and macrophages play pivotal role in the process of inflammation. In this study, we focused on the pathophysiological role of "hepatic crown-like structure (hCLS)", where macrophages surround dead hepatocytes in the novel rodent model of human NASH using melanocortin 4 receptor deficient mice. Our data provide evidence that hCLS-constitiuing macrophages are the source of fibrogenic factors, and promote inflammation and fibrosis in the development of NASH.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Eicosapentaenoic acid ameliorates non-alcoholic steatohepatitis in a novel mouse model using Melanocortin 4 receptor-deficient mice.2015
Author(s)
K. Konuma, M. Itoh, T. Suganami, S. Kanai, N. Nakagawa, T. Sakai, H. Kawano, M. Hara, S. Kojima, Y. Izumi, Y. Ogawa.
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Journal Title
PLoS One
Volume: 10
Issue: 3
Pages: e0121528-e0121528
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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