Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Outline of Final Research Achievements |
We investigated panreatectomised wild-type and IRS-2-KO mice to larify the role of IRS-2 in pancreatic beta cells. IRS-2 mice showed hyperglycemia and hypoinsulinemia after a pancreatectomy(Px), and oral administration of hypoglycemic agents improved the insulin secretion.The inslulin secretion of isolated islets from Px IRS-2 mice were not impaired regardless of normalization of blood glucose levels. In addition, normalization of hyperglycemia in Px IRS-2 mice did not decrease the beta cell proliferation after a pancreatectomy in IRS-2 mice. These data suggests that the beta cell proliferation after a pancreatectomy is independent of insulin signal mediated IRS-2, or glucose signal,and that the function of regenerative beta cells have normal function.
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