The mechanism of pancreatic beta cell proliferation after a pancreatectomy

• Project/Area Number: 26860698
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Metabolomics
• Research Institution: Yokohama City University
• Principal Investigator: TOGASHI YU 横浜市立大学, 医学部, 助教 (10710444)
• Research Collaborator: TERAUCHI Yasuo ; SHIRAKAWA Jun ; TAJIMA Kazuki ; ORIME Kazuki
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 膵β細胞 / 糖尿病 / 再生 / 2型糖尿病

Outline of Final Research Achievements

We investigated panreatectomised wild-type and IRS-2-KO mice to larify the role of IRS-2 in pancreatic beta cells. IRS-2 mice showed hyperglycemia and hypoinsulinemia after a pancreatectomy(Px), and oral administration of hypoglycemic agents improved the insulin secretion.The inslulin secretion of isolated islets from Px IRS-2 mice were not impaired regardless of normalization of blood glucose levels. In addition, normalization of hyperglycemia in Px IRS-2 mice did not decrease the beta cell proliferation after a pancreatectomy in IRS-2 mice. These data suggests that the beta cell proliferation after a pancreatectomy is independent of insulin signal mediated IRS-2, or glucose signal,and that the function of regenerative beta cells have normal function.

Research Products

• [Journal Article] β cell proliferation after a partial pancreatectomy is independent of IRS-2 in mice. (2014)
  • Author(s): Togashi Y, Shirakawa J, Orime K, Kaji M, Sakamoto E, Tajima K, Inoue H, Nakamura A, Tochino Y, Goshima Y, Shimomura I, Terauchi Y.
  • Journal Title: Endocrinology Volume: 155 Issue: 5 Pages: 1643-52
  • DOI: 10.1210/en.2013-1796
  • Peer Reviewed
• [Journal Article] Using miglitol at 30 min before meal is effective in hyperinsulinemic hypoglycemia after a total gastrectomy (2014)
  • Author(s): Shirakawa J, Murohashi Y, Okazaki N, Yamazaki S, Tamura T, Okuyama T, Togashi Y, Terauchi Y.
  • Journal Title: Endocrine Journal Volume: 61 Issue: 11 Pages: 1115-1123
  • DOI: 10.1507/endocrj.EJ14-0290
  • NAID: 130004677955
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Metoformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 mice. (2014)
  • Author(s): Tajima K, Nakamurar A, Shirakawa J, Togashi Y, Orime K, Sato K, Inoue H, Kaji M, Sakamoto E, Ito Y, Aoki K, Nagashima Y, Atsumi T, Terauchi Y.
  • Journal Title: Am J Physiol Endocrinol Metab Volume: 305
  • Peer Reviewed
• [Presentation] 膵部分切除マウスによる新規膵β細胞増殖シグナルの探索 (2016)
  • Author(s): 富樫 優、白川 純、田島 一樹、折目和基、寺内 康夫
  • Organizer: 第30回日本糖尿病・肥満動物学会.
  • Place of Presentation: 大宮ソニックシティホール（埼玉県さいたま市）
  • Year and Date: 2016-03-11
• [Presentation] 膵部分切除マウスによる新規膵β細胞増殖シグナルの探索 (2015)
  • Author(s): 富樫 優、白川 純、田島 一樹、山崎 俊介、小西 裕美、寺内 康夫
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: 海峡メッセ下関（山口県下関市）
  • Year and Date: 2015-05-21 – 2015-05-23
• [Presentation] 膵部分切除マウスによる膵β細胞増殖シグナルの探索 (2015)
  • Author(s): 富樫 優、白川 純、奥山 朋子、吉田 瑛子、京原 麻由、山崎 俊介、井上 英昭、折目 和基、伊藤 譲、寺内 康夫
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: 海峡メッセ下関（山口県下関市）
  • Year and Date: 2015-05-21
• [Presentation] 膵部分切除マウスにおける膵β細胞増殖機構の解明 (2014)
  • Author(s): 富樫 優、白川 純、折目和基、田島一樹、井上英昭、坂本絵里、梶美津代、寺内康夫
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2014-05-22 – 2014-05-24