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Regulation of NLRP3 inflammasome by modulation of lipid metabolisms

Research Project

Project/Area Number 26860699
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Metabolomics
Research InstitutionJichi Medical University

Principal Investigator

Karasawa Tadayoshi  自治医科大学, 医学部, 助教 (60631893)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords飽和脂肪酸 / 炎症 / サイトカイン / マクロファージ / インフラマソーム / 脂肪酸組成
Outline of Final Research Achievements

Saturated fatty acids (SFAs) provoke NLRP3 inflammasome acitivation and subsequent IL-1beta release in macrophages. However, precise mechanisms by which SFAs activate NLRP3 inflamasome remain unclear. In this study, we clarified inflammasome activation provked by SFAs was attenuated by treatment with unsaturated fatty acids (USFAs). Furthermore, SFA-induced lysosomal dysfunction was recovered by treatment with USFAs. These results suggest that lysosomal dysfunction induced by SFA overload provokes activation of NLRP3 inflammasome.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] RIP140 as a novel therapeutic target in the treatment of atherosclerosis.2015

    • Author(s)
      Karasawa T, Takahashi M.
    • Journal Title

      Journal of Molecular and Cellular Cardiology

      Volume: 81 Pages: 136-138

    • DOI

      10.1016/j.yjmcc.2015.02.009

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 脂肪酸結晶によるNLRP3インフラマソームを介した炎症惹起機構の解析2016

    • Author(s)
      唐澤直義, 臼井文武, 川島晃, 木村博昭, 高橋将文
    • Organizer
      第37回日本炎症・再生医学会
    • Place of Presentation
      京都市勧業館 みやこめっせ(京都府京都市)
    • Year and Date
      2016-06-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 脂肪酸の飽和/不飽和バランスの破綻によるインフラマソーム活性化機構の解析2015

    • Author(s)
      唐澤直義
    • Organizer
      Atherosclerosis & Cardiovascular Research Conference
    • Place of Presentation
      ホテルサンルートプラザ新宿(東京都新宿区)
    • Year and Date
      2015-12-19
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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