Regulation of NLRP3 inflammasome by modulation of lipid metabolisms

Research Project

Project/Area Number	26860699
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Metabolomics
Research Institution	Jichi Medical University
Principal Investigator	Karasawa Tadayoshi 自治医科大学, 医学部, 助教 (60631893)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	飽和脂肪酸 / 炎症 / サイトカイン / マクロファージ / インフラマソーム / 脂肪酸組成
Outline of Final Research Achievements	Saturated fatty acids (SFAs) provoke NLRP3 inflammasome acitivation and subsequent IL-1beta release in macrophages. However, precise mechanisms by which SFAs activate NLRP3 inflamasome remain unclear. In this study, we clarified inflammasome activation provked by SFAs was attenuated by treatment with unsaturated fatty acids (USFAs). Furthermore, SFA-induced lysosomal dysfunction was recovered by treatment with USFAs. These results suggest that lysosomal dysfunction induced by SFA overload provokes activation of NLRP3 inflammasome.

Report

(3 results)