The elucidation of the role of zinc signal in adipocyte browning
| Project/Area Number |
26860700
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 亜鉛トランスポーター / 脂肪細胞褐色化 / ベージュ脂肪細胞 / 亜鉛輸送 / エネルギー消費 / 亜鉛シグナル / 脂肪褐色化 / 肥満 / 2型糖尿病 |
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| Outline of Final Research Achievements |
Brown fat tissue in adult humans is composed mainly of beige-like adipocytes. The molecular circuits involved in beige adipocyte biogenesis and thermogenesis have not been fully elucidated. Here, we demonstrate that Zip13-KO preferentially promotes beige adipocyte biogenesis and energy expenditure, and ameliorates diet-induced obesity. Furthermore, ZIP13-mediated zinc transport is a prerequisite for inhibiting beige adipocyte differentiation. Our data reveal an unexpected association between zinc homeostasis and beige adipocyte biogenesis, which may contribute significantly to new therapies for obesity.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy.2014
Author(s)
Shigihara N, Fukunaka A, Hara A, Komiya K, Honda A, Uchida T, Abe H, Toyofuku Y, Tamaki M, Ogihara T, Miyatsuka T, Hiddinga HJ, Sakagashira S, Koike M, Uchiyama Y, Yoshimori T, Eberhardt NL, Fujitani Y, Watada H.
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Journal Title
J Clin Invest.
Volume: 124
Issue: 8
Pages: 3634-44
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Molecular pathogenesis of Spondylocheirodysplastic Ehlers-Danlos syndrome caused by mutant ZIP13 proteins2014
Author(s)
Bin BH, Hojyo S, Hosaka T, Bhin J, Kano H, Miyai T, Ikeda M, Kimura-Someya T, Shirouzu M, Cho EG, Fukue K, Kambe T, Ohashi W, Kim KH, Seo J, Choi DH, Nam YJ, Hwang D, Fukunaka A, Fujitani Y, Yokoyama S, Superti-Furga A, Ikegawa S, Lee TR and Fukada T
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Journal Title
EMBO Mol. Med.
Volume: 9
Pages: 1028-42
Related Report
Peer Reviewed / Open Access
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