| Project/Area Number |
26860703
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Hokkaido University |
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Principal Investigator |
Yoneshiro Takeshi 北海道大学, 獣医学研究科, 学振特別研究員(PD) (40724167)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 褐色脂肪 / 肥満 / 糖尿病 / 評価法 / 食品成分 / 褐色脂肪組織 / 新規評価法 / 糖代謝 |
|---|
| Outline of Final Research Achievements |
Brown adipose tissue (BAT) is a promising target to fight diabetes. Although positron emission tomography and computed tomography (PET/CT) is a powerful tool to assess human BAT, it has serious concerns including radiation exposure. We successfully developed a novel technique, near-infrared time-resolved spectroscopy (NIRS-TRS), by which we could estimate intraindividual difference of BAT density/activity. BAT activity determined intraindividual variation of cold-induced thermogenesis according to season. Moreover, BAT activity was a significant determinant of blood glucose and HbA1c independently of age, sex, body fat content, and visceral fat area. We also revealed in mice that royal jelly is a new food ingredient activating BAT and improving diet-induced insulin resistance. Our findings could contributes to develop the BAT-targeting antiobesity and antidiabetic regimen in humans.
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