Development of novel method for evaluation of human brown fat and search for brown fat-derived antidiabetec factors
| Project/Area Number |
26860703
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Hokkaido University |
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Principal Investigator |
Yoneshiro Takeshi 北海道大学, 獣医学研究科, 学振特別研究員(PD) (40724167)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 褐色脂肪 / 肥満 / 糖尿病 / 評価法 / 食品成分 / 褐色脂肪組織 / 新規評価法 / 糖代謝 |
|---|
| Outline of Final Research Achievements |
Brown adipose tissue (BAT) is a promising target to fight diabetes. Although positron emission tomography and computed tomography (PET/CT) is a powerful tool to assess human BAT, it has serious concerns including radiation exposure. We successfully developed a novel technique, near-infrared time-resolved spectroscopy (NIRS-TRS), by which we could estimate intraindividual difference of BAT density/activity. BAT activity determined intraindividual variation of cold-induced thermogenesis according to season. Moreover, BAT activity was a significant determinant of blood glucose and HbA1c independently of age, sex, body fat content, and visceral fat area. We also revealed in mice that royal jelly is a new food ingredient activating BAT and improving diet-induced insulin resistance. Our findings could contributes to develop the BAT-targeting antiobesity and antidiabetic regimen in humans.
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Report
(3 results)
Research Products
(53 results)
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[Journal Article] <i>Kaempferia parviflora</i> Extract Increases Whole-Body Energy Expenditure in Humans: Roles of Brown Adipose Tissue2015
Author(s)
Matsushita M, Yoneshiro T, Aita S, Kamiya T, Kusaba N, Yamaguchi N, Takagaki K, Kameya T, Sugie H, Saito M.
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Journal Title
Journal of Nutritional Science and Vitaminology
Volume: 61
Issue: 1
Pages: 79-83
DOI
NAID
ISSN
0301-4800, 1881-7742
Related Report
Peer Reviewed / Open Access
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[Presentation] エネルギー代謝学と性差2016
Author(s)
米代武司
Organizer
第9回日本性差医学・医療学会学術集会
Place of Presentation
北海道札幌市, ニューオータニイン札幌
Year and Date
2016-01-30
Related Report
Invited
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[Presentation] Green tee catechin increases brown fat-dependent thermogenesis2015
Author(s)
Yoneshiro T, Matsushita M, Tone H, Hibi M, Takeshita M, Yasunaga K, Katsuragi Y, Saito M
Organizer
Keystone Symposia on Molecular and Cellular Biology -Beige and Brown Fat: Basic Biology and Novel Therapeutics
Place of Presentation
Snowbird Resort, Snowbird, Utah, USA
Year and Date
2015-04-20
Related Report
Int'l Joint Research
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[Presentation] Verification of human brown adipose tissue evaluation using near-infrared time-resolved spectroscopy2015
Author(s)
Nirengi S, Amagasa S, Homma T, Yoneshiro T, Kurosawa Y, Iida T, Oda M, Yamashita Y, Saito M, Hamaoka T
Organizer
International Symposium on Human Adaptation to Environment and Whole-body Coordination
Place of Presentation
Kobe, Japan
Year and Date
2015-03-14 – 2015-03-16
Related Report
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