Effect of ATF3 induced by stress on glucose metabolism in the liver

• Project/Area Number: 26860705
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Endocrinology
• Research Institution: Kanazawa University
• Principal Investigator: Watanabe Hitoshi 金沢大学, 脳・肝インターフェースメディシン研究センター, 博士研究員 (50721495)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 肝臓 / 糖代謝 / ストレス / 糖尿病

Outline of Final Research Achievements

The role of hepatic stress response in insulin resistance and glucose metabolism is not elucidated enough. Through this study, we have clarified expression of ATF3, is transcription factor induced by stress, increased in the condition of obesity and insulin resistance and the induction of endoplasmic reticulum. Then, phosphorylation of STAT3, inhibits the expression of glucose production related gene in the liver, by IL-6 was decreased. These results suggest that there is possibility that ATF3 and STAT3 in the liver regulate the glucose metabolism.

Research Products

• [Journal Article] Centra insulin-action activates Kupffer cells by suppressing hepatic vagal activation through nicotinic alpha 7 acetylcholine receptor. (2016)
  • Author(s): Kimura K, Tanida M, Nagata N, Inaba Y, Watanabe H, Nagashimada M, Ota T, Asahara S, Kido Y, Matsumoto M, Toshinai K, Nakazato M, Shibamoto T, Kaneko S, Kasuga M, Inoue H
  • Journal Title: Cell reports Volume: 14 Issue: 10 Pages: 2362-2374
  • DOI: 10.1016/j.celrep.2016.02.032
  • Peer Reviewed / Open Access
• [Journal Article] Serotonin improves high fat diet induced obesity in mice. (2016)
  • Author(s): Watanabe H.†, Nakano T.†, Saito R.†, Akasaka D., Saito K., Ogasawara H., Minashima T., Miyazawa K., Kanaya T., Takakura I., Inoue N., Ikeda I., Chen X., Miyake M., Kitazawa H., Shirakawa H., Sato K., Tahara K., Nagasawa Y., Rose M.T., Ohwada S., Watanabe K., Aso H.
  • Journal Title: PLoS One Volume: 11 Issue: 1 Pages: 1-14
  • DOI: 10.1371/journal.pone.0147143
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The stimulatory effect of plasma samples from fattening cattle on adipogenesis related gene expression in preadipocyte cells (2015)
  • Author(s): Hitoshi WATANABE, Xiangning CHEN, Noriaki SHOJI, Ryo SAITO, Tatsuya NAKANO, Kazuki SAITO, Keisuke SUMIYOSHI, Michael T. ROSE, Natumi OKADA, Kouichi WATANABE and Hisashi ASO
  • Journal Title: Animal Science Journal Volume: 86 Issue: 7 Pages: 698-706
  • DOI: 10.1111/asj.12344
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gadd34 regulates liver regeneration in hepatic steatosis. (2015)
  • Author(s): Inaba Y, Furutani T, Kimura K, Watanabe H, Haga S, Kido Y, Yamamoto Y, Harada K, Kaneko S, Oyadomari S, Ozaki M, Kasuga M, Inoue H.
  • Journal Title: Hepatology Volume: 61(4) Issue: 4 Pages: 1343-1356
  • DOI: 10.1002/hep.27619
  • Peer Reviewed / Open Access