| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In the patients with hypothalamus-pituitary disorders,impairment of reproductive functions often occurs. As a factor surrounding GH/IGF-1 hormone, we paid attention to a melatonin. Melatonin receptors were detected in GnRH neurons and ovaries, suggesting that melatonin plays a functional role in the reproductive system not only centrally but also peripherally in the ovary. we studied the role of melatonin in ovarian steroidogenesis regulated by BMP-6 using rat primary granulosa cells of immature female rat ovaries. As a result of discussion, it was shown that melatonin plays a key role in the regulation of BMP-6 signal intensity for controlling progesterone production in the ovary.
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