Identification of inflammasome binding protein and novel signal pathway

• Project/Area Number: 26860710
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Endocrinology
• Research Institution: Jichi Medical University
• Principal Investigator: Kawashima Akira 自治医科大学, 医学部, 研究員 (60624913)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 免疫 / インフラマソーム / ユビキチン / ユビキチン化

Outline of Final Research Achievements

The purpose of this study is to identify the inflammasome activation system. Firstly we performed comprehensive analysis of inflammasome components by TOF-MS. In result we found that certain type of E3 ubiquitin ligase binds one of the inflammasome components and ubiquitination. And this molecule inhibits inflammasome activation through degradation of inflammasome components. These results reveal the pathway that regulates the inflammasome through the ubiquitination and degradation.