To clarify the mechanism of overeating in obesity - the involvement of microglial activation and neural plasticity in the brain reward system
| Project/Area Number |
26860712
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Keio University |
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Principal Investigator |
Nobuko Yamada-Goto 慶應義塾大学, 医学部(信濃町), 特別研究員(RPD) (50400891)
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| Research Collaborator |
NAKAE Jun 慶應義塾大学, 医学部, 特任准教授
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 肥満症 / 過食 / 報酬系 / マイクログリア / 脳内炎症 / 神経可塑性 / 慢性炎症 / 摂食調節 / 減量治療 / 炎症 / Foxo1 / ドーパミン神経系 |
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| Outline of Final Research Achievements |
Overeating is one of the core symptom and the reason of obesity. My hypothesis is the inflammatory changes both in neurons and microglia in the brain reward system due to high-fat feeding may cause overeating. Therefore, in this study, I examined high-fat-feeding male C57BL/6J mice. High-fat feeding for 2 weeks caused elevation of inflammatory cytokines and activation of microglia in the hypothalamus and hippocampus which are related to reward system. Weight reduction by means of food changes from high-fat diet to normal chow, led the hypothalamic and hippocampal mRNA expressions into close pattern of those in mice fed on continously normal chow only.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Neuronal cells derived from human induced pluripotent stem cells as a functional tool of melanocortin system.2017
Author(s)
N. Yamada-Goto, Y. Ochi, G. Katsuura, Y. Yamashita, K. Ebihara, M. Noguchi, J. Fujikura, D. Taura, M. Sone, K. Hosoda, P.E. Gottschall, K. Nakao.
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Journal Title
Neuropeptides
Volume: 印刷中
Pages: 10-20
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Brain-specific natriuretic peptide receptor-B deletion attenuates high-fat diet-induced visceral and hepatic lipid deposition in mice.2016
Author(s)
Yamashita Y, Yamada-Goto N, Katsuura G, Ochi Y, Kanai Y, Miyazaki Y, Kuwahara K, Kanamoto N, Miura M, Yasoda A, Ohinata K, Inagaki N, Nakao K.
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Journal Title
Peptides
Volume: 81
Pages: 38-50
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Neuronal cells derived from human induced pluripotent stem cells as a functional tool of melanocortin system.2016
Author(s)
Yamada-Goto N, Ochi Y, Katsuura G, Yamashita Y, Ebihara K, Noguchi M, Fujikura J, Taura D, Sone M, Hosoda K, Gottschall PE, Nakao K.
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Journal Title
Neuropeptides
Volume: submitted
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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