Elucidation of a mechanism of organ tropism in malignant lymphoma to develop novel treatment for intractable extranodal involvement
Project/Area Number |
26860724
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Hematology
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Research Institution | Nagoya University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | 悪性リンパ腫 / 腫瘍微小環境 / 節外臓器浸潤 / 微小環境 |
Outline of Final Research Achievements |
Although clinical outcomes of malignant lymphoma have been improved due to the application of monoclonal antibody therapies, the outcomes of extranodal involvement including central nervous system during the clinical course are still intractable. In this study, we investigated an underlying mechanism of organ specific lymphoma development using patient derived xenograft models. We could uncover that the inhibition of cell migration was potentially associated with a pathogenesis in intravascular large B-cell lymphoma. Moreover we focused on an amplification of chromosome 19q known to be involved in extranodal B-cell lymphoma. We could also uncover SPIB, a member of the Ets family of transcription factors located on chromosome 19q, was novel poor prognostic factor in diffuse large B-cell lymphoma through an anti-apoptotic mechanism.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] YM155 induces apoptosis through proteasome-dependent degradation of MCL-1 in primary effusion lymphoma.2017
Author(s)
Kojima Y, Hayakawa F, Morishita T, Sugimoto K, Minamikawa Y, Iwase M, Yamamoto H, Hirano D, Imoto N, Shimada K, Okada S, Kiyoi H
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Journal Title
Pharmacol Res.
Volume: in press
Pages: 242-251
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Emetine elicits apoptosis of intractable B-cell lymphoma cells with MYC rearrangement through inhibition of glycolytic metabolism.2017
Author(s)
Aoki T, Shimada K, Sakamoto A, Sugimoto K, Morishita T, Kojima Y, Shimada S, Kato S, Iriyama C, Kuno S, Harada Y, Tomita A, Hayakawa F, Kiyoi H.
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Journal Title
Oncotarget.
Volume: 8
Issue: 8
Pages: 13085-13098
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Development and analysis of patient derived xenograft mouse models in intravascular large B-cell lymphoma. Leukemia.2016
Author(s)
Shimada K, Shimada S, Sugimoto K, Nakatochi M, Suguro M, Hirakawa A, Hocking TD, Takeuchi I, Tokunaga T, Takagi Y, Sakamoto A, Aoki T, Naoe T, Nakamura S, Hayakawa F, Seto M, Tomita A, Kiyoi H
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Journal Title
Leukemia
Volume: in press
Issue: 7
Pages: 1568-1579
DOI
Related Report
Peer Reviewed
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[Presentation] Emetine Elicits Apoptosis of Intractable B-Cell Lymphoma Cells with MYC Rearrangement through Inhibition of Glycolytic Metabolism2016
Author(s)
Aoki T, Shimada K, Sakamoto A, Sugimoto K, Morishita T, Kojima Y, Shimada S, Kato S, Iriyama C, Kuno S, Harada Y, Nakamura S, Tomita A, Hayakawa F, Kiyoi H.
Organizer
The 58th Annual Meeting and Exposition of the American Society of Hematology
Place of Presentation
San Diego (USA)
Year and Date
2016-12-03
Related Report
Int'l Joint Research
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[Presentation] Development and Analysis of Novel Intravascular Large B-Cell Lymphoma NOD/Shi-Scid IL2Rγnull Mouse Xenograft Model2014
Author(s)
Shimada K,Shimada S,Sugimoto K,Hayakawa F,Katayama M,Hirakawa A,Takagi Y, Nakamura S,Seto M,Naoe T,Tomita A,Kiyoi H.
Organizer
The 56th Annual Meeting of the American Society of Hematology.
Place of Presentation
San Francisco, USA
Year and Date
2014-12-05 – 2014-12-09
Related Report
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[Presentation] Biological and genetic analyses of intravascular large B-cell lymphoma using xenograft mouse model2014
Author(s)
Shimada K,Shimada S,Sugimoto K,Hayakawa F,Katayama M,Hirakawa A,Nakamura S,Seto M,Naoe T,Tomita A,Kiyoi H.
Organizer
第76回日本血液学会学術集会
Place of Presentation
大阪国際会議場(大阪府、大阪市)
Year and Date
2014-10-31 – 2014-11-02
Related Report
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