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Role of ARID5 in Rheumatoid Arthritis

Research Project

Project/Area Number 26860744
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Collagenous pathology/Allergology
Research InstitutionChiba University

Principal Investigator

Furuta Shunsuke  千葉大学, 医学(系)研究科(研究院), 特任講師 (10422221)

Research Collaborator NAKAJIMA Hiroshi  
IKEDA Kei  
HANAOKA Hideki  
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords内科 / 膠原病内科 / 関節リウマチ / ARID5 / CD4陽性T細胞 / ARID5A
Outline of Final Research Achievements

ARID5A was highly expressed in human and murine Th17 cells. Analysis with a Stat3 inhibitor and RORgt-deficient CD4 T cells revealed that the IL-6/Stat3 pathway directly induced ARID5A expression in CD4 T cells. Retrovirus-mediated induction of ARID5A in CD4 T cells resulted in the suppression of IL-17, IL-17F and IL-22 production but in the acceleration of IL-21 production. We also found that ARID5A directly bound to RORgt and inhibited RORgt-mediated suppression of IL-21 promoter activation, resulting in the acceleration of IL-21 expression. These results suggest that ARID5A functions as a switch molecule of IL-17-IL-21 balance in murine Th17 cells.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] AT-rich interactive domain-containing protein 5a functions as a negative regulator of RORγt-induced Th17 cell differentiation.2014

    • Author(s)
      Saito Y, Kagami SI, Sanayama Y, Ikeda K, Suto A, Kashiwakuma D, Furuta S, Iwamoto I, Nonaka K, Ohara O, Nakajima H.
    • Journal Title

      Arthritis and Rheumatology

      Volume: 印刷中 Issue: 5 Pages: 1185-94

    • DOI

      10.1002/art.38324

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prediction of therapeutic responses to tocilizumab in patients with rheumatoid arthritis – biomarkers identified by analyses of gene expression in peripheral blood mononuclear cells using genome-wide DNA microarray2014

    • Author(s)
      Sanayama Y, Ikeda K, Saito Y, Kagami S, Yamagata M, Furuta S, Kashiwakuma D, Iwamoto I, Umibe T, Nawata Y, Matsumura R, Sugiyama T, Sueishi M, Hiraguri M, Nonaka K, Ohara O, Nakajima H
    • Journal Title

      Arthritis Rheumatol

      Volume: in press Issue: 6 Pages: 1421-1431

    • DOI

      10.1002/art.38400

    • Related Report
      2014 Research-status Report
    • Peer Reviewed

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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