Role of ARID5 in Rheumatoid Arthritis
Project/Area Number |
26860744
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Collagenous pathology/Allergology
|
Research Institution | Chiba University |
Principal Investigator |
Furuta Shunsuke 千葉大学, 医学(系)研究科(研究院), 特任講師 (10422221)
|
Research Collaborator |
NAKAJIMA Hiroshi
IKEDA Kei
HANAOKA Hideki
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 内科 / 膠原病内科 / 関節リウマチ / ARID5 / CD4陽性T細胞 / ARID5A |
Outline of Final Research Achievements |
ARID5A was highly expressed in human and murine Th17 cells. Analysis with a Stat3 inhibitor and RORgt-deficient CD4 T cells revealed that the IL-6/Stat3 pathway directly induced ARID5A expression in CD4 T cells. Retrovirus-mediated induction of ARID5A in CD4 T cells resulted in the suppression of IL-17, IL-17F and IL-22 production but in the acceleration of IL-21 production. We also found that ARID5A directly bound to RORgt and inhibited RORgt-mediated suppression of IL-21 promoter activation, resulting in the acceleration of IL-21 expression. These results suggest that ARID5A functions as a switch molecule of IL-17-IL-21 balance in murine Th17 cells.
|
Report
(3 results)
Research Products
(2 results)
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[Journal Article] AT-rich interactive domain-containing protein 5a functions as a negative regulator of RORγt-induced Th17 cell differentiation.2014
Author(s)
Saito Y, Kagami SI, Sanayama Y, Ikeda K, Suto A, Kashiwakuma D, Furuta S, Iwamoto I, Nonaka K, Ohara O, Nakajima H.
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Journal Title
Arthritis and Rheumatology
Volume: 印刷中
Issue: 5
Pages: 1185-94
DOI
Related Report
Peer Reviewed
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[Journal Article] Prediction of therapeutic responses to tocilizumab in patients with rheumatoid arthritis – biomarkers identified by analyses of gene expression in peripheral blood mononuclear cells using genome-wide DNA microarray2014
Author(s)
Sanayama Y, Ikeda K, Saito Y, Kagami S, Yamagata M, Furuta S, Kashiwakuma D, Iwamoto I, Umibe T, Nawata Y, Matsumura R, Sugiyama T, Sueishi M, Hiraguri M, Nonaka K, Ohara O, Nakajima H
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Journal Title
Arthritis Rheumatol
Volume: in press
Issue: 6
Pages: 1421-1431
DOI
Related Report
Peer Reviewed