| Project/Area Number |
26860749
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Kyoto University |
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Principal Investigator |
Hashimoto Motomu 京都大学, 医学(系)研究科(研究院), 助教 (60512845)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 全身性エリテマトーデス / 動物モデル / CD4 T細胞 / T細胞レセプターシグナル / Toll like receptor / SLE / 関節リウマチ / T細胞 / 自然免疫 |
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| Outline of Final Research Achievements |
SKG mouse on BALB/c background is a murine model for rheumatoid arthritis. We backcrossed SKG mice into C57BL/6 background to generate SKG mice on C57BL/c background (C57BL/6 ZAP70skg/skg mice; B6 SKG mice). B6 SKG mice developed lupus like nephritis with immune complex deposition and anti-DNA antibody production after chronic stimulation with Toll like receptors agonists. In B6 SKG mice, follicular helper T cells (CXCR5+, PD-1high, Bcl6+) were spontaneously expanded and helped forming the germinal center B cells (Fas+, GL-7+) to produce anti-DNA antibody.
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