Role of RANK expressed on FDCs in humoral immunity
Project/Area Number |
26860750
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Collagenous pathology/Allergology
|
Research Institution | Osaka University |
Principal Investigator |
TANAKA SHINYA 大阪大学, 免疫フロンティア研究センター, 特任助教 (80462703)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | FDC / RANK |
Outline of Final Research Achievements |
I examined roles of receptor activator of NF-kappa B (RANK) in humoral immune response in the research program. Our results suggest that the interaction between follicular dendritic cells (FDCs) and follicular helper T (Tfh) cells would promote T cell-dependent humoral immunity. In addition, I performed global gene expression analysis with stromal cell subsets using next generation sequencing. The assay provided unique gene expression patterns of each stromal cell subsets and revealed RANK receptor was highly expressed in stroma cells especially lymphatic endothelial cell (LEC) and/or LEC-like cells. The finding indicates that humoral immune response could be regulated by RANK expressed by these stromal cells. In addition, our gene expression data of stromal cells is useful information to understand role and function of stromal cells in host defense and immunopathological diseases.
|
Report
(3 results)
Research Products
(4 results)
-
[Journal Article] Genome-wide Analysis Identifies Bcl6-Controlled Regulatory Networks during T Follicular Helper Cell Differentiation2016
Author(s)
Liu, X. Lu, H. Chen, T. Nallaparaju, K. C. Yan, X. Tanaka, S. Ichiyama, K. Zhang, X. Zhang, L. Wen, X. Tian, Q. Bian, X. W. Jin, W. Wei, L. Dong, C.
-
Journal Title
Cell reports
Volume: 14
Pages: 1735-47
Related Report
Peer Reviewed / Int'l Joint Research
-
[Journal Article] The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells2015
Author(s)
Ichiyama, K. Chen, T. Wang, X. Yan, X. Kim, B. S. Tanaka, S. Ndiaye-Lobry, D. Deng, Y. Zou, Y. Zheng, P. Tian, Q. Aifantis, I. Wei, L. Dong, C.
-
Journal Title
Immunity
Volume: 42
Pages: 613-26
Related Report
Peer Reviewed / Int'l Joint Research
-
[Journal Article] CCAAT/enhancer-binding protein alpha negatively regulates IFN-gamma expression in T cells2014
Author(s)
Tanaka, S., Tanaka, K., Magnusson, F., Chung, Y., Martinez, G.J., Wang, Y.,Nurieva R.I., Kurosaki, T., Dong, C.
-
Journal Title
The journal of immunology
Volume: 193
Pages: 6152-60
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-