MicroRNA modulate the function of fibroblast-like cells inRheumatoid Arthritis
| Project/Area Number |
26860753
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Nagasaki University |
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Principal Investigator |
IWAMOTO Naoki 長崎大学, 医歯薬学総合研究科(医学系), 助教 (80437897)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 関節リウマチ / microRNA / 骨芽細胞 / 滑膜細胞 / メトトレキサート / トファシチニブ |
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| Outline of Final Research Achievements |
Fibroblast-like synovial cells from RA patients (RA-FLS) can differentiate into osteoblast and miR-218 was down-regulated during osteogenic differentiation of RA-FLS. Induction of miR-218 in RA-FLS decreased ROBO1 expression. Conversely, the knockdown of miR-218 increased the expression of ROBO1. Finally, miR-218 promoted osteogenic differentiation of RA-FLS through DKK-1 suppression. Our results showed that miR-218 modulate osteogenic differentiation of RA-FLS through ROBO1/DKK-1 axis. This attractive hypothesis needs to be further tested in animal models.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Evaluation of Switching from Intravenous to Subcutaneous Formulation of Tocilizumab in Patients with Rheumatoid Arthritis.2016
Author(s)
Iwamoto N, Fukui S,Umeda M, Nishino A, Nakashima Y, Suzuki T, Horai Y, Nonaka F, Okada A, Koga T, Kawashiri S, Fujikawa K, Aramaki T, Ichinose K, Hirai Y, Tamai M, Nakamura H, Terada K, Nakashima M, Mizokami A, Origuchi T, Eguchi K, Ueki Y, Kawakmi A.
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Journal Title
Modern Rheumatology
Volume: feb2
Pages: 1-5
Related Report
Peer Reviewed
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[Journal Article] Upregulation of Thrombospondin 1 Expression in Synovial Tissues and Plasma of Rheumatoid Arthritis: Role of Transforming Growth Factor-β1 toward Fibroblast-like Synovial Cells.2015
Author(s)
Suzuki T, Iwamoto N, Yamasaki S, Nishino A, Nakashima Y, Horai Y, Kawashiri SY, Ichinose K, Arima K, Tamai M, Nakamura H, Origuchi T, Miyamoto C, Osaki M, Ohyama K, Kuroda N, Kawakami A.
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Journal Title
Journal of Rheumatology
Volume: 42
Pages: 943-947
Related Report
Peer Reviewed
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