Environmental allergens affect the function of allergic inflammatory cells

Research Project

Project/Area Number	26860758
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Collagenous pathology/Allergology
Research Institution	Saitama Medical University
Principal Investigator	KOBAYASHI Takehito 埼玉医科大学, 医学部, 講師 (90618266)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	好酸球 / 気管支喘息 / 環境アレルゲン / アレルギー性炎症 / 室内塵ダニ / スギ花粉 / 接着反応 / 活性酸素産生 / ダニ抗原刺激 / 自然免疫
Outline of Final Research Achievements	Even without an allergic constitution in asthmatic patients, symptoms may be exacerbated by exposure to the allergen. We investigated whether house dust mites directly induce eosinophil adhesion and effector function. House dust mites significantly induced adhesion reaction and active superoxide production of eosinophils. Similar results were obtained with this specific reaction even with the specific protein Derf 1. It was suggested that indoor dust mites act directly on eosinophils and affect expression of effector functions.

Report

(4 results)