| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We analyzed an allergy march model in which allergic airway responses to intranasally administered papain are enhanced by prior subcutaneous/epicutaneous exposure to papain. We demonstrated the involvement of basophils and mast cells in the antibody response and allergic skin inflammation in response to subcutaneous papain administration. We found that in contrast to the papain-induced airway inflammation model, in which IL-33 and ILC2s play the central roles, IL-33-induced ILC2 activation is suppressed by a papain-inducible, skin-derived suppressive factor in the papain-induced skin inflammation model. We also reported that basophil IL-4 production in response to various allergens is dependent on FceRI γ-chain.
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