Analysis of CD8+CD26-positive/negative T cell subsets for the development of an innovative therapy and elucidating the pathophysiology of refractory autoimmune diseases
Project/Area Number |
26860760
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Collagenous pathology/Allergology
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Research Institution | Juntendo University |
Principal Investigator |
Hatano Ryo 順天堂大学, 医学(系)研究科(研究院), 特任研究員 (30638789)
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Research Collaborator |
ISHII Tomonori
SEKIGAWA Iwao
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | CD26/DPPIV / T細胞 / SLE / 自己免疫疾患 / 細胞傷害性T細胞 / 共刺激分子 / ヒト免疫 / 共刺激 / 細胞傷害活性 / IL-10 / CD26 |
Outline of Final Research Achievements |
CD26 is a T cell costimulatory molecule, and CD26+ T cells have been suggested to be involved in the pathophysiology of diverse autoimmune diseases. Since the role of CD26 in the pathophysiology of SLE still remains to be elucidated, our objective is to characterize the CD26-positive or negative T cell subsets in SLE patients. Human CD4+ or CD8+ T cells were purified from PBMCs of SLE patients or healthy adult volunteers, and we examined the phenotypes of CD26-positive or negative subsets. In addition to CD8+CD26nega T cells, CD4+CD26nega T cells were also markedly increased in SLE patients, and these cells exhibited CD28negaCD57+PerforinhiGranzyme Bhi cytotoxic potential. It takes more than 24 months for the patients with a large number of these subsets to reduce the daily dose of prednisolone to less than 10 mg after the initial treatment, strongly suggesting that CD26nega cytotoxic T cells are involved in the pathophysiology of steroid-resistant SLE.
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Report
(5 results)
Research Products
(33 results)
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[Journal Article] A possible role for CD26/DPPIV enzyme activity in the regulation of psoriatic pruritus2017
Author(s)
Komiya, E. Hatano, R. Otsuka, H. Itoh, T. Yamazaki, H. Yamada, T. Dang, N. H. Tominaga, M. Suga, Y. Kimura, U. Takamori, K. Morimoto, C. Ohnuma, K.
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Journal Title
J Dermatol Sci
Volume: 印刷中
Issue: 3
Pages: 212-221
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Regulation of somatostatin receptor 4-mediated cytostatic effects by CD26 in malignant pleural mesothelioma.2014
Author(s)
Yamamoto J, Ohnuma K, Hatano R, Okamoto T, Komiya E, Yamazaki H, Iwata S, Dang NH, Aoe K, Kishimoto T, Yamada T, Morimoto C.
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Journal Title
Br J Cancer.
Volume: Vol 110
Issue: 9
Pages: 2232-45
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] The regulation of pruritus in psoriasis and atopic dermatitis -a possible role for CD26/DPPIV.2017
Author(s)
Eriko Komiya, Ryo Hatano, Haruna Otsuka, Takumi Itoh, Hiroto Yamazaki, Taketo Yamada, Yasushi Suga, Utako Kimura, Mitsutoshi Tominaga, Kenji Takamori, Kei Ohnuma, Chikao Morimoto.
Organizer
9th World Congress on Itch, Novotel Centrum, Wroclaw, Poland
Related Report
Int'l Joint Research
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[Book] Advances in Medicine and Biology2018
Author(s)
Hatano R, Ohnuma K, Yamada T, Okamoto T, Komiya E, Otsuka H, Itoh T, Yamazaki H, Iwao N, Kaneko Y, Dang NH, Morimoto C.
Total Pages
44
Publisher
Nova Science Publishers, Inc., Hauppauge, NY
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