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Development of analytical tools for elucidating functions of epidermal gd T cells

Research Project

Project/Area Number 26860761
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Collagenous pathology/Allergology
Research InstitutionJuntendo University

Principal Investigator

SHIMURA Eri  順天堂大学, 医学部, 准教授 (30586342)

Research Collaborator NAKAE Susumu  東京大学, 医科学研究所, 准教授 (60450409)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords表皮gdT細胞 / 皮膚免疫 / gdT細胞 / アレルギー / 接触性皮膚炎 / 皮膚 / 皮膚免疫応答 / γδT細胞
Outline of Final Research Achievements

DETC (dendritic epidermal T cell), a γδ T cell present in the epidermis, has been shown to have an important role in skin diseases such as wound healing, skin cancer and contact dermatitis. However, the role of DETC in the skin immune response remains unclear. In the background it seemed that there was still no useful tool specialized for DETC analysis.
In this research, for the purpose of constructing analysis method for elucidating the function of DETC, we screened 4 genes that code for molecules expressed on DETC.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2016 2014

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Loss of Dok-1 and Dok-2 in mice causes severe experimental colitis accompanied by reduced expression of IL-17A and IL-22.2016

    • Author(s)
      Waseda M, Arimura S, Shimura E, Nakae S, and Yamanashi Y
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 478 Issue: 1 Pages: 135-142

    • DOI

      10.1016/j.bbrc.2016.07.079

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] IL-25, IL-33 and TSLP receptor are not critical for development of experimental murine malaria2016

    • Author(s)
      Akiko Shibuia, Ayako Takamori, Mohammed E.M. Tolbaa, Aya Nambu, Eri Shimura, Sachiko Yamaguchi, Chizu Sanjoba, Hajime Suto, Katsuko Sudo, Ko Okumura, Sumio Sugano, Hideaki Morita, Hirohisa Saito, Kenji Matsumoto, Susumu Nakae
    • Journal Title

      Biochemistry and Biophysics Reports

      Volume: 5 Pages: 191-195

    • DOI

      10.1016/j.bbrep.2015.12.007

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Potential role of myeloid cell/eosinophil-derived IL-17 in LPS-induced endotoxin shock.2014

    • Author(s)
      Shimura E, Shibui A, Narushima S, Nambu A, Yamaguchi S, Akitsu A, Leonard WJ, Iwakura Y, Matsumoto K, Suto H, Okumura K, Sudo K, Nakae S
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 453 Issue: 1 Pages: 1-6

    • DOI

      10.1016/j.bbrc.2014.09.004

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access

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Published: 2014-04-04   Modified: 2019-03-29  

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