Roles of connective tissue fibroblasts in the pathogenesis of atopic dermatitis
| Project/Area Number |
26860765
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
ANDO Tomoaki 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 研究員 (10724669)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | アトピー性皮膚炎 / 線維芽細胞 / PLC-beta3 / SPS複合体 / PLC-β3 |
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| Outline of Final Research Achievements |
We investigated the mechanisms underlying hyper-expression of Periostin in phospholipase C (PLC)-beta3 deficient fibroblasts. In addition, we examined the in vitro effects of PLC-beta3 supplement therapy. Stimulation by IL-13, which is known to activate Periostin production, induced hyper phosphorylation of both Stat5 and Stat6 in PLC-beta3 deficient fibroblasts. On the other hand, transfection of fibroblasts with fusion proteins of PLC-beta3 fragment and SHP-1 suppressed the activation of Stat5 and Stat6. These results would serve as a basis for developing new therapeutics for the atopic dermatitis targeting SHP-1-PLC-beta3-Stat5 (SPS) complex.
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Report
(3 results)
Research Products
(4 results)
