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Roles of connective tissue fibroblasts in the pathogenesis of atopic dermatitis

Research Project

Project/Area Number 26860765
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Collagenous pathology/Allergology
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

ANDO Tomoaki  国立研究開発法人理化学研究所, 統合生命医科学研究センター, 研究員 (10724669)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsアトピー性皮膚炎 / 線維芽細胞 / PLC-beta3 / SPS複合体 / PLC-β3
Outline of Final Research Achievements

We investigated the mechanisms underlying hyper-expression of Periostin in phospholipase C (PLC)-beta3 deficient fibroblasts. In addition, we examined the in vitro effects of PLC-beta3 supplement therapy. Stimulation by IL-13, which is known to activate Periostin production, induced hyper phosphorylation of both Stat5 and Stat6 in PLC-beta3 deficient fibroblasts. On the other hand, transfection of fibroblasts with fusion proteins of PLC-beta3 fragment and SHP-1 suppressed the activation of Stat5 and Stat6. These results would serve as a basis for developing new therapeutics for the atopic dermatitis targeting SHP-1-PLC-beta3-Stat5 (SPS) complex.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2015 2014

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Invited: 1 results)

  • [Journal Article] Hypothetical atopic dermatitis-myeloproliferative neoplasm syndrome.2015

    • Author(s)
      Kawakami, T., Ando, T., and Kawakami, Y.
    • Journal Title

      Front. Immunol.

      Volume: 6 Pages: 434-434

    • DOI

      10.3389/fimmu.2015.00434

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Suplatast tosilate for treating cutaneous mastocytosis2015

    • Author(s)
      Yasudo, H., Ando, T., Hiwatari, M., and Oka, A.
    • Journal Title

      Pediatric Dermatology

      Volume: 32 Issue: 3

    • DOI

      10.1111/pde.12552

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] アトピー性皮膚炎の新しいメカニズムと創薬への応用2015

    • Author(s)
      安藤智暁
    • Organizer
      アトピー性皮膚炎の新薬開発と理想的な治療像
    • Place of Presentation
      技術情報協会・品川区・東京
    • Year and Date
      2015-12-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Mast cells and the Stat5 activation pathway are required for allergen-induced and spontaneous skin inflammation2014

    • Author(s)
      Tomoaki Ando, Jun-ichi Kashiwakura, Yuko Kawakami, Toshiaki Kawakami
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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