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The dynamics of immune cells and pneumococcus were analyzed by live imaging technique

Research Project

Project/Area Number 26860768
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Infectious disease medicine
Research InstitutionYamaguchi University

Principal Investigator

OGINO Hidetaka  山口大学, 医学(系)研究科(研究院), 助教 (80589325)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords細菌学 / 感染症 / イメージング / 細菌性髄膜炎 / ワクチン / 免疫学
Outline of Final Research Achievements

Bacterial meningitis is highly onset and progression to severe in infants. The risk of poor prognosis (a cerebral infarction or deafness) is known to be high. Pneumococcus and Haemophilus influenzae are known to be the major causative organisms. In recent years, drug-resistant bacteria have been increasing, and treatments are becoming difficult in some cases. For that reason prevention with vaccines is important.
In this study, the dynamics of immune cells and pneumococcus were analyzed by live imaging technique. As a result, formation of infection focus inside the lung was observed. Moreover, accumulation of immune cells inside the lung was also observed.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2017 2016 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (6 results)

  • [Journal Article] Adaptive mutation related to cellulose producibility in Komagataeibacter medellinensis (Gluconacetobacter xylinus) NBRC 3288.2015

    • Author(s)
      Matsutani M, Ito K, Azuma Y, Ogino H, Shirai M, Yakushi T, Matsushita K.
    • Journal Title

      Appl Microbiol Biotechnol

      Volume: 99 Issue: 17 Pages: 7229-7240

    • DOI

      10.1007/s00253-015-6598-x

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 腸炎の発症におけるCD69 の役割2017

    • Author(s)
      長谷川 明洋,荻野 英賢,中山 俊憲,白井 睦訓
    • Organizer
      第90回日本細菌学会総会
    • Place of Presentation
      宮城県(仙台国際センター)
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 環境中に存在する細菌の高温適応機構の解明2016

    • Author(s)
      荻野 英賢、長谷川 明洋、淺岡 洋一、松谷 峰之介、白井 睦訓
    • Organizer
      第69回日本細菌学会中国四国支部総会
    • Place of Presentation
      香川県(かがわ国際会議場)
    • Year and Date
      2016-10-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] Identification of genes that contribute to the temperature-resistance in acetic acid bacterium.2016

    • Author(s)
      Hidetaka Ogino, Akihiro Hasegawa, Minenosuke Matsutani, Kazunobu Matsushita, Youichi Mizukami, Mutsunori Shirai
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪府大阪市)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Research-status Report
  • [Presentation] CD69ノックアウトマウスでみられた腸炎の抑制2015

    • Author(s)
      長谷川 明洋、荻野 英賢、大津山 賢一郎、中山 俊憲、白井 睦訓
    • Organizer
      第88回日本細菌学会総会
    • Place of Presentation
      長良川国際会議場(岐阜)
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 肺炎原因菌検出における Multiplex NASBA- 核酸クロマト法の評価2015

    • Author(s)
      知識 麻友子、宇治家 武史、荻野 英賢、長谷川 明洋、江崎 孝行、白井 睦訓
    • Organizer
      第88回日本細菌学会総会
    • Place of Presentation
      長良川国際会議場(岐阜)
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 肺炎原因菌の感染巣における動態観察2014

    • Author(s)
      荻野 英賢、大津山 賢一郎、長谷川 明洋
    • Organizer
      第4回動く細胞と場のクロストーク若手の会
    • Place of Presentation
      火の国ハイツ(熊本)
    • Year and Date
      2014-09-04 – 2014-09-05
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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