Assessment of Sudden Cardiac Death Risk in Children with Early Repolarization by Magnetocardiography

• Project/Area Number: 26860782
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: University of Tsukuba
• Principal Investigator: Kato Yoshiaki 筑波大学, 医学医療系, 講師 (90635608)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 早期再分極症候群 / 心磁図 / Ｊ波症候群 / 特発性心室細動 / 突然死 / 学校心臓検診 / 心室細動 / Ｊ波

Outline of Final Research Achievements

We assessed the utility of clinical application of magnetocardiography (MCG) in assessment of risk of sudden cardiac death in children with early repolarization (J wave) in electrocardiogram. We analyzed 7,540 electrocardiograms of healthy children obtained in school screening. J wave was observed in 12.8% of boys in the seventh grade. We analyzed 91 MCG records of J wave syndrome. Using current vector arrow map of MCG, we could identify the characteristic abnormal current in Brugada syndrome cases. We could visualize current arrow of J wave in three dimensions, however there was no consistent current vector pattern in other J wave syndrome cases. In this study, we failed to show the utility of MCG in assessment of risk of sudden cardiac death. However, MCG analysis using current vector arrow map may be helpful in assessment of electrophysiological property of J wave.

Research Products

• [Journal Article] Cardiac resynchronization therapy in a patient with a failing systemic right ventricle. (2015)
  • Author(s): Sugano A, Ishizu T, Nakamura A, Kawamatsu N, Kato Y, Takahashi M, Kanemoto S, Seo Y, Horigome H, Hiramatsu Y, Aonuma K
  • Journal Title: Can J Cardiol Volume: 31(6) Issue: 6 Pages: 819.e5-819.e7
  • DOI: 10.1016/j.cjca.2015.01.004
  • Peer Reviewed
• [Journal Article] Significant associations between hemostatic/fibrinolytic systems and accumulation of cardiovascular risk factors in Japanese elementary school children. (2015)
  • Author(s): Lin L, Horigome H, Kato Y, Kikuchi T, Nakahara S, Sumazaki R.
  • Journal Title: Blood Coagulation & Fibrinolysis Volume: 26 Issue: 1 Pages: 75-80
  • DOI: 10.1097/mbc.0000000000000187
  • Peer Reviewed
• [Presentation] 心房筋の進行性の線維化を認めたSCN5A変異を伴う心房静止例 (2015)
  • Author(s): 加藤愛章、野崎良寛、林立申、中村昭宏、高橋実穂、堀米仁志
  • Organizer: 第24回日本小児心筋疾患学会
  • Place of Presentation: 大阪、グランフロント大阪
  • Year and Date: 2015-10-24
• [Presentation] 低形成中心肺動脈を有する肺動脈閉鎖、心室中隔欠損、主要体肺側副動脈に対する姑息的右室流出路形成を含めた肺血流の調整 (2015)
  • Author(s): 加藤愛章、高橋実穂、林立申、野崎良寛、中村昭宏、堀米仁志、松原宗明、平松祐司
  • Organizer: 第51回日本小児循環器学会学術集会
  • Place of Presentation: 東京、ホテル日航東京
  • Year and Date: 2015-07-16
• [Presentation] Progressive Atrial Myocardial Fibrosis in A 4-year-old Girl with Atrial Standstill Associated with SCN5A Gene Mutation (2015)
  • Author(s): Yoshiaki Kato, Yoshihiro Nozaki, Miho Takahashi-Igari, Lisheng Lin, Akihiro Nakamura, Hitoshi Horigome
  • Organizer: Ｈｅａｒｔ Ｒｈｙｔｈｍ ２０１５， 36ｔｈ Ａｎｎｕａｌ Ｓｃｉｅｎｔｉｆｉｃ Ｓｅｓｓｉｏｎｓ
  • Place of Presentation: Boston
  • Year and Date: 2015-05-13 – 2015-05-15
• [Presentation] Progressive Atrial Myocardial Fibrosis in A 4-year-old Girl with Atrial Standstill Associated with SCN5A Gene Mutation (2015)
  • Author(s): Yoshiaki Kato, Yoshihiro Nozaki, Miho Takahashi-Igari, Lisheng Lin, Akihiro Nakamura, Hitoshi Horigome
  • Organizer: Heart Rhythm 2015 - 36th Annual Scientific Sessions
  • Place of Presentation: 米国、ボストン
  • Year and Date: 2015-05-13
  • Int'l Joint Research
• [Presentation] Heart Rate Variability Analysis Using Fetal Magnetocardiography Predicts Prognosis of Fetuses with Heart Failure Combined with Congenital Heart Disease (2015)
  • Author(s): Yoshiaki Kato, Lisheng Lin, Miho Takahashi-Igari, Kuniomi Ogata, Akihiko Kandori, Akihiro Nakamura, Yoshihiro Nozaki, Hitoshi Horigome
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Heart Rate Variability Analysis Using Fetal Magnetocardiography Predicts Prognosis of Fetuses with Heart Failure Combined with Congenital Heart Disease (2015)
  • Author(s): Yoshiaki Kato, Lisheng Lin, Miho Takahashi-Igari, Kuniomi Ogata, Akihiko Kandori, Akihiro Nakamura, Yoshihiro Nozaki, Hitoshi Horigome
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪市、大阪国際会議場
  • Year and Date: 2015-04-24
• [Presentation] Analysis of Heart Rate Variability Using Fetal Magnetocardiography in Fetuses with Congenital Heart Disease (2014)
  • Author(s): Yoshiaki Kato, Miho Takahashi-Igari, Lisheng Lin, Kuniomi Ogata, Akihiko Kandori, Akihiro Nakamura, Yoshihiro Nozaki, Hitoshi Horigome
  • Organizer: 第29回日本不整脈学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2014-07-22 – 2014-07-25
• [Presentation] 抗SS-A抗体陽性母体の胎児における心磁図を用いた心拍変動解析 (2014)
  • Author(s): 加藤愛章、高橋実穂、林立申、緒方邦臣、中村昭宏、堀米仁志、須磨崎亮
  • Organizer: 第50回日本小児循環器学会総会・学術集会
  • Place of Presentation: 岡山市
  • Year and Date: 2014-07-03 – 2014-07-05