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Cardiac function assessment for cardiac anomalies based on hemodynamic analysis

Research Project

Project/Area Number 26860783
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionNational Center for Child Health and Development

Principal Investigator

HAYASHI Taiyu  国立研究開発法人国立成育医療研究センター, 器官病態系内科部, 医師 (70597129)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords心エコー検査 / 小児 / 先天性心疾患 / 心機能 / 心臓超音波検査 / 心筋ストレイン解析 / 心エコー / 右室機能評価 / 弁膜症 / 左室拡張能 / 血流ネルギー損失
Outline of Final Research Achievements

Echocardiographic evaluation is essential in daily clinical practice for children with heart diseases. In this study, we aimed to establish normative values and clinical decision criteria of the following echocardiographic indices in children.
(1) We showed that dissipative energy loss within the left ventricle was associated with left ventricular diastolic dysfunction. (2) We obtained normative values for a mitral valve coaptation depth, and showed that the effectiveness of the mitral valve plasty for functional mitral valve regurgitation in children with dilated cardiomyopathy could be predicted by the coaptation depth. (3) We established the diagnostic criteria of Doppler-derived hemodynamic parameters for prosthetic mitral valve obstruction in children. (4) We demonstrated that the indices of right ventricular longitudinal function did not properly reflect right ventricular systolic function in children with repaired Tetralogy of Fallot.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (25 results)

All 2017 2016 2015 2014

All Journal Article (9 results) (of which Peer Reviewed: 7 results,  Acknowledgement Compliant: 4 results) Presentation (16 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Echocardiographic assessment of prosthetic mitral valves in children.2017

    • Author(s)
      Hayashi T, Inuzuka R, Ono H, Kato H.
    • Journal Title

      Echocardiography

      Volume: 34 Issue: 1 Pages: 94-101

    • DOI

      10.1111/echo.13406

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 小児心筋炎に対する体外式膜型人工肺を用いた治療2017

    • Author(s)
      浦田晋、林泰佑、西村奈穂、中川聡、小野博
    • Journal Title

      日本小児科学会雑誌

      Volume: 121 Pages: 536-542

    • NAID

      40021141806

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional TAPVC via levoatriocardinal vein.2016

    • Author(s)
      Hayashi T, Ozawa K, Sugibayashi R, Wada S, Ono H
    • Journal Title

      Pediatrics International

      Volume: 58 Issue: 7 Pages: 656-659

    • DOI

      10.1111/ped.12920

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Clinical implications of mitral valve geometric alterations in children with dilated cardiomyopathy.2016

    • Author(s)
      Hayashi T, Inuzuka R, Shindo T, Ono H, Kaneko Y, Kato H.
    • Journal Title

      Cardiology in the Young

      Volume: 26 Issue: 7 Pages: 1365-1372

    • DOI

      10.1017/s1047951115002668

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Author's reply to PMID 255955592016

    • Author(s)
      Hayashi T, Itatani K.
    • Journal Title

      Journal of Cardiology

      Volume: 67 Issue: 1 Pages: 122-123

    • DOI

      10.1016/j.jjcc.2015.07.005

    • Related Report
      2015 Research-status Report
  • [Journal Article] Dissipative Energy Loss Within the Left Ventricle Detected by Vector Flow Mapping in Children: Normal Values and Effects of Age and Heart Rate.2015

    • Author(s)
      Hayashi T, Itatani K, Inuzuka R, et al.
    • Journal Title

      Journal of Cardiology

      Volume: NA Issue: 5 Pages: 403-410

    • DOI

      10.1016/j.jjcc.2014.12.012

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Total anomalous pulmonary venous connection with ccTGA and VSD: Can pulmonary artery banding avert pulmonary venous obstruction?2015

    • Author(s)
      Hayashi T, Inuzuka R, Hirata Y, et al.
    • Journal Title

      Pediatrics International

      Volume: 57 Issue: 4 Pages: 714-716

    • DOI

      10.1111/ped.12580

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 正常小児のvector flow mapping2015

    • Author(s)
      林 泰佑
    • Journal Title

      循環器内科

      Volume: 77 Pages: 200-204

    • Related Report
      2014 Research-status Report
  • [Journal Article] Serum hyaluronic acid concentration in Fontan circulation: correlation with hepatic function and portal vein hemodynamics.2014

    • Author(s)
      Hayashi T1, Inuzuka R, Shindo T, Hirata Y, Shimizu N, Oka A.
    • Journal Title

      Pediatric Cardiology

      Volume: 35 Issue: 4 Pages: 608-615

    • DOI

      10.1007/s00246-013-0827-9

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 右室容量負荷を有する先天性心疾患術後小児において、三尖弁輪収縮期移動距離と移動速度のz値は右室収縮能を反映するか?2017

    • Author(s)
      林泰佑、清水信隆、三崎泰志、小野博
    • Organizer
      第28回日本心エコー図学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 小児肥大型心筋症患者の定期経過観察心エコー検査における死亡予測因子2017

    • Author(s)
      林泰佑、進藤考洋、犬塚亮、清水信隆、三崎泰志、小野博
    • Organizer
      第53回日本小児循環器学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Left ventricular end-diastolic diameter obtained during follow-up echocardiography predicts mortality in children with hypertrophic cardiomyopathy2017

    • Author(s)
      Hayashi T, Shindo T, Inuzuka R, Ono H, Kato H
    • Organizer
      7th World Congress of Pediatric Cardiology and Cardiac Surgery
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Echocardiographic assessment of ventricular contraction and synchrony in children with isolated complete atrioventricular block and epicardial pacing2017

    • Author(s)
      Hayashi T, Shimizu N, Misaki Y, Ono H
    • Organizer
      21st Annual Meeting of the European Association of Cardiovascular Imaging
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Age-adjusted indices of right ventricular (RV) longitudinal function do not adequately reflect the global RV contraction in children with repaired congenital heart defects and RV volume overload.2016

    • Author(s)
      Hayashi T, Shimizu N, Misaki Y, Ono H
    • Organizer
      20th Annual Meeting of the European Association of Cardiovascular Imaging
    • Place of Presentation
      Leipzig (Germany)
    • Year and Date
      2016-12-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 小児における僧帽弁位人工弁の心エコーによる評価―人工弁狭窄を見逃さないために―2016

    • Author(s)
      林泰佑,犬塚亮,真船亮,浦田晋,金子正英,三崎泰志,小野博,賀藤均
    • Organizer
      第52回日本小児循環器学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Echocardiographic assessment of prosthetic mitral valve in children.2016

    • Author(s)
      Hayashi T, Inuzuka R, Ono H, Kato H
    • Organizer
      50th Annual Meeting of the Association for European Paediatric and Congenital Cardiology
    • Place of Presentation
      Rome (Italy)
    • Year and Date
      2016-06-01
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 小児における僧帽弁位人工弁の心エコーによる評価2016

    • Author(s)
      林泰佑 ほか
    • Organizer
      第27回日本心エコー図学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2016-04-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Functional total anomalous pulmonary venous drainage via levoatriocardinal vein: Clues to prenatal diagnosis.2015

    • Author(s)
      Mafune R, Hayashi T, Kaneko M, et al.
    • Organizer
      19th Annual Meeting of the European Association of Cardiovascular Imaging
    • Place of Presentation
      Seville, Spain
    • Year and Date
      2015-12-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 拡張型心筋症小児におけるテザリングによる僧帽弁の変形の臨床的意義2015

    • Author(s)
      林泰佑 ほか
    • Organizer
      第51回日本小児循環器学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-16
    • Related Report
      2015 Research-status Report
  • [Presentation] Clinical Implication of Mitral Valve Geometry Alterations in Children with Dilated Cardiomyopathy.2015

    • Author(s)
      Hayashi T, Shindo T, Inuzuka R, et al.
    • Organizer
      49th Annual Meeting of the Association for European Paediatric and Congenital Cardiology
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2015-05-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 下心臓型TAPVCを伴うccTGA, VSD~肺動脈絞扼術で新生児期の開心術を回避した治療戦略2015

    • Author(s)
      林泰佑 ほか
    • Organizer
      第118回日本小児科学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 拡張期の左室内エネルギー損失と左室拡張能との関連2015

    • Author(s)
      林泰佑,板谷慶一,進藤考洋ほか
    • Organizer
      第26回日本心エコー図学会学術集会
    • Place of Presentation
      北九州
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Dissipative Energy Loss within the Left Ventricle during Diastole Reflects Left Ventricular Diastolic Function.2014

    • Author(s)
      Hayashi T, Itatani K, Inuzuka R, et al.
    • Organizer
      18th Annual Meeting of the European Association of Cardiovascular Imaging
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2014-12-03 – 2014-12-06
    • Related Report
      2014 Research-status Report
  • [Presentation] Dissipative Energy Loss within the Left Ventricle Detected by Vector Flow Mapping in Children: Normal Values and Effects of Age, Heart Rate, and Preload2014

    • Author(s)
      Hayashi T, Itatani K, Inuzuka R, et al.
    • Organizer
      48th Annual Meeting of the Association for European Paediatric and Congenital Cardiology
    • Place of Presentation
      Helsinki, Finland
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Research-status Report
  • [Presentation] Vector Flow Mappingを用いた左室内血流のエネルギー損失の計測:小児の基準値と年齢・心拍数・前負荷の影響2014

    • Author(s)
      林泰佑,板谷慶一,犬塚亮ほか
    • Organizer
      第25回日本心エコー図学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2014-04-17 – 2014-04-19
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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