Development of novel mesothelin-specific immunotherapy for treating pediatric refractory acute myeloid leukemia
Project/Area Number |
26860790
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Pediatrics
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Research Institution | Shinshu University |
Principal Investigator |
YANAGISAWA Ryu 信州大学, 医学部附属病院, 特任研究員 (80532043)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | メソセリン / 細胞傷害性T細胞 / 免疫療法 / 樹状細胞 / 細胞傷害性T細胞 |
Outline of Final Research Achievements |
We attempted to generate mesothelin-specific cytotoxic T lymphocytes (CTLs) for developing novel immunotherapy for treating refractory pediatric acute myeloid leukemia. We cultured monocytes from peripheral blood mononuclear cells in a cytokine mix for 1 week so that monocytes could differentiate into dendritic cells. Furthermore, we attempted to generate mesothelin-specific CTLs after stimulating T lymphocytes with mesothelin-peptide-pulsed dendritic cells and a cytokine mix. Although we were unable to effectively generate mesothelin-specific CTLs, we found variable specificity in the generated mesothelin-specific CTLs. We believe our method needs further improvements before it can be applied clinically.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] Preoperative Treatment With Pazopanib in a Case of Chemotherapy-Resistant Infantile Fibrosarcoma2016
Author(s)
Yanagisawa R, Noguchi M, Fujita K, Sakashita K, Sano K, Ogiso Y, Katsuyama Y, Kondo Y, Komori K, Fujihara I, Kitamura R, Hiroma T, Nakamura T
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Journal Title
Pediatric Blood & Cancer
Volume: 63
Issue: 2
Pages: 348-351
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Temozolomide Treatment for Pediatric Refractory Anaplastic Ependymoma with Low MGMT Protein Expression2016
Author(s)
Komori K, Yanagisawa R, Miyairi Y, Sakashita K, Shiohara M, Fujihara I, Morita D, Nakamura T, Ogiso Y, Sano K, Shirahata M, Fukuoka K, Ichimura K, Shigeta H
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Journal Title
Pediatric Blood & Cancer
Volume: 63
Issue: 1
Pages: 152-155
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Pretransplant-corrected QT dispersion as a predictor of pericardial effusion after pediatric hematopoietic stem cell transplantation.2015
Author(s)
Yanagisawa R, Ishii E, Motoki N, Yamazaki S, Morita D, Sakashita K, Shiohara M, Tanaka M, Hidaka Y, Kubota N, Hidaka E, Ogiso Y, Nakamura T, Yasukochi S
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Journal Title
Transplant International
Volume: 28
Issue: 5
Pages: 565-74
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Interleukin-8-producing primary cardiac undifferentiated sarcoma in a child with sustained fever2015
Author(s)
Yanagisawa R, Nakamura T, Ogiso Y, Hachiya A, Fujihara I, Morita D, Sakashita K, Kitamura M, Matsui H, Nishijima F, Hayashi H, Hidaka E, Sano K, Shiohara M, Yasukochi S
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Journal Title
Pediatrics International
Volume: in press
Issue: 4
Pages: 742-745
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Pretransplant corrected QT dispersion as a predictor of pericardial effusion associated with thrombotic microangiopathy after pediatric hematopoietic stem cell transplantation2015
Author(s)
R. Yanagisawa, E. Ishii, N. Motoki, S. Yamazaki, D. Morita, K. Sakashita, M. Shiohara, M. Tanaka, Y. Hidaka, N. Kubota, E. Hidaka, Y. Ogiso, T. Nakamura, S. Yasukochi
Organizer
41st Annual Meeting of the European Society for Blood and Marrow Transplantation
Place of Presentation
Istanbul, Turkey
Year and Date
2015-03-22 – 2015-03-25
Related Report
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