| Project/Area Number |
26860791
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 接合菌症 / 養子免疫 / 接合菌血清診断 / 造血幹細胞移植 / 免疫不全症 / 接合菌特異的T細胞 / 養子免疫療法 / 接合菌溶菌液 / 接合菌 / 真菌 / 接合菌特異的PCR / 真菌特異的Ｔ細胞 / 免疫不全 / 慢性肉芽腫症 |
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| Outline of Final Research Achievements |
Although mucormycosis is a fatal complication in immunocompromised patients, there are no specific or useful serum biomarkers for diagnosing mucormycosis. A definitive diagnosis of mucormycosis is based on histopathological findings, molecular detection, and/or a positive culture in the affected tissue. We modified the qPCR assay (targeting Mucor/Rhizopus, Lichtheimia, and Rhizomucor) which Millon et al. had reported to indicate the absolute amount for the monitoring of activity of mucormycosis. In addition, we could purify Mucorales lysate and amplify fungus-specific T cells using aspergillus which were a representative filamentous fungi fungus and the dendritic cells.
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