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The role of microRNA for pediatric idiopathic nephrotic syndrome

Research Project

Project/Area Number 26860800
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionKobe University

Principal Investigator

Matsunoshita Natsuki  神戸大学, 医学研究科, 医学研究員 (70622885)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsネフローゼ症候群 / podocyte / 網羅的診断体制 / 次世代シークエンサー / 小児特発性ネフローゼ症候群 / 蛋白尿惹起因子 / podocyte障害 / マイクロRNA
Outline of Final Research Achievements

It has already been identified that 45 genes are responsible for steroid resistant nephrotic syndrome (SRNS). Among SRNS cases, 30% of them are caused by mutations in some genes. In addition, those cases are resistant to various immunosuppressive therapies and develop to end-stage renal disease but doesn't show SRNS relapse after kidney transplantation.
We have established the comprehensive gene testing system using next generation sequencer and conducted gene tests for 63 families. Among them, we identified gene mutations in 28% of them. Moreover, those cases never responded to immunosuppressive therapies. We will identify molecular mechanisms for the onset of SRNS and character of clinical courses of each gene mutations in Japan.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2016

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 2 results)

  • [Journal Article] Somatic mosaicism and variant frequency detected by next-generation sequencing in X-linked Alport syndrome.2016

    • Author(s)
      Fu XJ, Nozu K, Kaito H, Ninchoji T, Morisada N, Nakanishi K, Yoshikawa N, Ohtsubo H, Matsunoshita N, Kamiyoshi N, Matsumura C, Takagi N, Maekawa K, Taniguchi-Ikeda M, Iijima K
    • Journal Title

      Eur J Hum Genet

      Volume: 24 Issue: 3 Pages: 387-391

    • DOI

      10.1038/ejhg.2015.113

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathogenesis of hypokalemia in autosomal dominant hypocalcemia type 1.2016

    • Author(s)
      Kamiyoshi N, Nozu K, Urahama Y, Matsunoshita N, Yamamura T, Minamikawa S, Ninchoji T, Morisada N, Nakanishi K, Kaito H, Iijima K.
    • Journal Title

      Clin Exp Nephrol.

      Volume: 20 Issue: 2 Pages: 253-257

    • DOI

      10.1007/s10157-015-1160-9

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Differential diagnosis of Bartter syndrome, Gitelman syndrome, and pseudo-Bartter/Gitelman syndrome based on clinical characteristics2016

    • Author(s)
      Matsunoshita N, Nozu K, Shono A, Nozu Y, Fu XJ, Morisada N, Kamiyoshi N, Ohtsubo H, Ninchoji T, Minamikawa S, Yamamura T, Nakanishi K, Yoshikawa N, Shima Y, Kaito H, Iijima K
    • Journal Title

      Genetics in Medicine

      Volume: 18 Issue: 2 Pages: 180-188

    • DOI

      10.1038/gim.2015.56

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant

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Published: 2014-04-04   Modified: 2018-03-22  

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