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Identification of disease gene and pathologic analysis of congental thrombocytopenia

Research Project

Project/Area Number 26860805
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionHiroshima University

Principal Investigator

Kobayashi Yoshiyuki  広島大学, 大学病院, 医科診療医 (20723290)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords血小板減少症 / インテグリンシグナル / 恒常的活性化状態 / 先天性血小板減少症
Outline of Final Research Achievements

We tried to identificate new candidate gene of thrombocytopenia, but we could not identificate disease gene in our study cases. We also performed functional analysis of integrin outside-in signal to elcidate the mechanism of thrombocytopenia and platelet dysfunction. As the mechanism of them, the relevance of inactivation of RhoA signaling has been suggested, but the involvement of other signaling pathways could not be proven. Further investigetions are necessary to elcidate the mechanism and obtain the beneficial outcome in the treatment and management of patients.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2014

All Presentation (1 results)

  • [Presentation] インテグリンβ3(GPIIIa) 遺伝子変異を同定できた先天性血小板減少症の2家系2014

    • Author(s)
      小林良行
    • Organizer
      第117回日本小児科学会学術集会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2014-04-11 – 2014-04-13
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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