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Detection of ovomucoid-specific low-affinity IgE in infants

Research Project

Project/Area Number 26860806
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionThe University of Tokushima

Principal Investigator

Kamemura Norio  徳島大学, 生物資源産業学部(仮称)設置準備室, 助教 (10632656)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords低親和性IgE / 低親和性特異的IgE / 抗原特異的IgE / アレルギー
Outline of Final Research Achievements

Immunoglobulin E (IgE) plays key roles in type I hypersensitivity in allergic individuals. We previously demonstrated the detection of antigen-specific low-affinity IgE in cord blood, but not after birth. We investigated the presence of low-affinity IgE during the infants’ early life.We found allergen-specific low-affinity sIgE in human infant peripheral blood even after birth.Further studies are needed to elucidate the roles of low-affinity IgE and of their affinity maturation to high-affinity after birth.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Measurement of allergen-specific secretory IgA in stool of neonates, infants and toddlers by protection against degradation of immunoglobulins and allergens2015

    • Author(s)
      Norio Kamemura, Miwa Takashima, Hideaki Morita, Kenji Matsumoto, Hirohisa Saito, and Hiroshi Kido
    • Journal Title

      J Med Invest

      Volume: 印刷中

    • NAID

      130005099155

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Application of moisturizer to neonates prevents development of atopic dermatitis.2014

    • Author(s)
      Horimukai K, Morita K, Narita M, Kondo M, Kitazawa H, Nozaki M, Shigematsu Y, Yoshida K, Niizeki H, Motomura K, Sago H, Takimoto T, Inoue E, Kamemura N, Kido H, Hisatsune J, Sugai M, Murota H, Katayama I, Sasaki T, Amagai M, Morita H, Matsuda A, Matsumoto K, Saito H, Ohya Y.
    • Journal Title

      The Journal of allergy and clinical immunology.

      Volume: 134 Issue: 4 Pages: 824-830

    • DOI

      10.1016/j.jaci.2014.07.060

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Detection of Ovomucoid-Specific Low-Affinity IgE in 14-Month-Old Infants and Its Relationship with Eczema2016

    • Author(s)
      Norio Kawamoto, Norio Kamemura, Hiroshi Kido, Toshiyuki Fukao
    • Organizer
      American Academy of Allergy Asthma and Immunology
    • Place of Presentation
      Los Angeles (America)
    • Year and Date
      2016-03-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 第64回日本アレルギー学会学術大会2015

    • Author(s)
      亀村典生, 高島美和, 森田英明, 松本健治, 斎藤博久, 木戸博
    • Organizer
      新生児、乳児便中の抗原特異的SIgAの新測定法
    • Place of Presentation
      グランドプリンスホテル高輪 (東京都品川区)
    • Year and Date
      2015-05-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新規蛋白チップによる臍帯血特異的IgEの検出と、離乳完了期までに見られるIgE抗体の低親和性から高親和性への変化2014

    • Author(s)
      亀村典生
    • Organizer
      日本小児アレルギー学会
    • Place of Presentation
      四日市市文化会館(三重県四日市市)
    • Year and Date
      2014-11-08 – 2014-11-09
    • Related Report
      2014 Research-status Report
  • [Presentation] 臍帯血中の抗原特異的Low Affinity IgEの検出と生後High Affinity IgEへの変化2014

    • Author(s)
      亀村典生
    • Organizer
      日本生化学大会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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