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The development of bone marrow transplantation as a treatment for hyper-IgE syndrome

Research Project

Project/Area Number 26860807
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionThe University of Tokushima

Principal Investigator

SAITO Masako  徳島大学, 大学院医歯薬学研究部, 助教 (00723892)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords高IgE症候群 / STAT3 / 骨髄移植 / アトピー性皮膚炎 / 高IgE血症
Outline of Final Research Achievements

To determine the relative contribution of hematopoietic versus non-hematopoietic cells to the high serum IgE phenotype in STAT3-donimant negative (DN) hyper-IgE syndrome, we generated wild-type (WT) or STAT3-DN bone marrow chimeras into WT or STAT3-DN recipient mice. Irradiated STAT3-DN recipients reconstituted with WT bone marrow showed normal serum IgE levels at 8 weeks after the transplantation. In contrast, increased serum IgE levels were observed in WT recipients received bone marrow cells from STAT3-DN donor. These results suggest that STAT3-DN hematopoietic cells are primary cause of high serum IgE phenotype in STAT3-DN hyper-IgE syndrome.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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