The development of bone marrow transplantation as a treatment for hyper-IgE syndrome

• Project/Area Number: 26860807
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: The University of Tokushima
• Principal Investigator: SAITO Masako 徳島大学, 大学院医歯薬学研究部, 助教 (00723892)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 高IgE症候群 / STAT3 / 骨髄移植 / アトピー性皮膚炎 / 高IgE血症

Outline of Final Research Achievements

To determine the relative contribution of hematopoietic versus non-hematopoietic cells to the high serum IgE phenotype in STAT3-donimant negative (DN) hyper-IgE syndrome, we generated wild-type (WT) or STAT3-DN bone marrow chimeras into WT or STAT3-DN recipient mice. Irradiated STAT3-DN recipients reconstituted with WT bone marrow showed normal serum IgE levels at 8 weeks after the transplantation. In contrast, increased serum IgE levels were observed in WT recipients received bone marrow cells from STAT3-DN donor. These results suggest that STAT3-DN hematopoietic cells are primary cause of high serum IgE phenotype in STAT3-DN hyper-IgE syndrome.