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Immunological and Platelet Functions in Patients after Fontan Operation: Gene Expression Microarray Analysis

Research Project

Project/Area Number 26860822
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionKitasato University

Principal Investigator

HONDA TAKASHI  北里大学, 医学部, 助教 (50525532)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsFontan循環 / マイクロアレイ / 遺伝子発現 / 免疫機能 / 血小板機能
Outline of Final Research Achievements

We performed microarray analysis for the blood cells in order to elucidate the mechanisms of abnormalities in immune system and platelet function in the Fontan patients. 6 Fontan patients and 6 children without any congenital heart diseases were enrolled in the present study. There were significant differences in 40 gene pathways. Among them, 5 pathways were associated with immune system (reduced IL-12 signaling, reduced PD-1 signaling, reduced ZAP-70 signaling, and reduced T cell receptor signaling in CD8+ T cells) and 1 was associated with platelet function (enhanced IFN alfa IIb/beta3). The results of our microarray analysis indicated that the cell-mediated immunity and humoral immunity are repressed and that the platelet function is enhanced in the Fontan patients.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2015

All Presentation (1 results)

  • [Presentation] 先天性心疾患の血行動態変化評価:microRNAアレイ解析2015

    • Author(s)
      本田崇、高梨学、野元けい子、峰尾恵梨、北川篤史、安藤寿、木村純人、岡徳彦、宮地鑑、石井正浩
    • Organizer
      第51回日本小児循環器学会総会・学術集会
    • Place of Presentation
      ホテル日航東京(東京都港区)
    • Year and Date
      2015-07-16
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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