| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Spinal muscular atrophy is a neurodegenerative disorder caused by the deficient expression of survival motor neuron protein in motor neurons. In SMA patients, SMN protein derived from SMN2 gene plays an important role. In this study, we developed the imaging flow cytometry method having both functions of fluorescence microscope system and flow cytometry method as an analysis method for SMN protein. Using this method, we revealed the expression patterns and subcellular localization of SMN protein in SMA patient-derived fibroblasts and lymphoblasts.
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