| Project/Area Number |
26860834
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
Nishimura Sawa 福岡歯科大学, 口腔歯学部, 医員 (20707187)
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| Research Collaborator |
Ishikawa Hiroyuki 福岡歯科大学, 学長 (20184492)
Sawa Yoshihiko 福岡歯科大学, 口腔歯学部, 教授 (70271666)
Inada Hiroko 佐賀県医療センター好生館, 小児科, 部長 (90223221)
Suita Sachiyo 福岡学園, 理事長 (30038856)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 歯の形成障害 / 小児腫瘍学 / 化学療法 / 歯の形成 / 口腔関連 QOL / 小児科学 |
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| Outline of Final Research Achievements |
This study aimed to investigate the laterality of tooth formation anomalies in pediatric cancers. The 46 long-term survivors treated for pediatric cancers were divided into two groups to analyze for the incidence of tooth agenesis (TA) and microdonts (MO): a conventional chemotherapy (CC, n=26); a high-dose chemotherapy followed by blood stem cell transplantation (HDC, n=20). It was revealed that anti-cancer chemotherapies induce TA/MO more in maxilla than in mandible symmetrically and HDC is prone to induce asymmetrical TA/MO in mandible. The mandible is a free bone supplied by the inferior alveolar artery whereas the maxilla is a complex supplied by the sphenopalatine artery, posterior and anterior superior alveolar arteries, and greater palatine artery. It is thought that anti-cancer treatments affect tooth buds stronger in maxilla than in mandible based on the blood supply, and the laterality of blood supply may induce the laterality of TA/MO.
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