| Project/Area Number |
26860835
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
SEKI Fumio 国立感染症研究所, その他部局等, 研究員 (20443111)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Pタンパク質 / 細胞膜透過配列 / 麻疹ウイルス / 細胞膜透過ペプチド / パラミクソウイルス |
|---|
| Outline of Final Research Achievements |
In our previous study, we detected the specific amino acid sequence, P336-507, has effect to inhibit virus replication. We succeeded in purifying the cell penetrating peptides-fused P336-507 protein by using Ni resin after expression with Escherichia coli. And after adding the cell penetrating peptides-fused P336-507 protein to the medium, the proteins existed in the cytoplasm. Then we elucidated the effects of the cell penetrating peptides-fused protein on inhibition of virus replication.
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