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Understanding the pathogenesis of L-asparaginase-associated pancreatitis

Research Project

Project/Area Number 26860838
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research Institution独立行政法人国立病院機構長良医療センター(臨床研究部)

Principal Investigator

Funato Michinori  独立行政法人国立病院機構長良医療センター(臨床研究部), その他部局等, その他 (30420350)

Research Collaborator OSAFUNE Kenji  京都大学, iPS細胞研究所, 准教授 (80502947)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords急性膵炎 / iPS細胞 / 膵外分泌機能不全 / 疾患モデル / 国際研究者交流
Outline of Final Research Achievements

L-asparaginase-associated pancreatitis is occasionally life-limiting, thus cell-based assay may be helpful to understand the mechanism of the important problem. Currently, we established efficient differentiation methods for pancreatic exocrine acinar cells from human iPSCs by identifying a small molecule. The induced exocrine acinar cells showed the synthesis and release of functional alpha-amylase protein, and contributed morphogenesis of acinar structure formation. Furthermore, we established in vitro disease models by applying iPSCs derived from the patient with Shwachman-Diamond syndrome, a congenital disorder characterized by exocrine insufficiency.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2015

All Presentation (1 results) (of which Invited: 1 results)

  • [Presentation] ヒトiPS細胞技術を用いた膵外分泌細胞の高効率分化誘導法の構築と応用2015

    • Author(s)
      舩戸道徳
    • Organizer
      SAM研究協議会
    • Place of Presentation
      岐阜大学サテライトキャンパス
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report
    • Invited

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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