Understanding the pathogenesis of L-asparaginase-associated pancreatitis
| Project/Area Number |
26860838
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | 独立行政法人国立病院機構長良医療センター(臨床研究部) |
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Principal Investigator |
Funato Michinori 独立行政法人国立病院機構長良医療センター(臨床研究部), その他部局等, その他 (30420350)
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| Research Collaborator |
OSAFUNE Kenji 京都大学, iPS細胞研究所, 准教授 (80502947)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 急性膵炎 / iPS細胞 / 膵外分泌機能不全 / 疾患モデル / 国際研究者交流 |
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| Outline of Final Research Achievements |
L-asparaginase-associated pancreatitis is occasionally life-limiting, thus cell-based assay may be helpful to understand the mechanism of the important problem. Currently, we established efficient differentiation methods for pancreatic exocrine acinar cells from human iPSCs by identifying a small molecule. The induced exocrine acinar cells showed the synthesis and release of functional alpha-amylase protein, and contributed morphogenesis of acinar structure formation. Furthermore, we established in vitro disease models by applying iPSCs derived from the patient with Shwachman-Diamond syndrome, a congenital disorder characterized by exocrine insufficiency.
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Report
(3 results)
Research Products
(1 results)
